Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 0.48 |
| ▸ | ADAMTS5 | Q9UNA0 | 5/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12233004 | 0.91 | ACHE (0.40) | MMP2ADAMTS5GAAACHECHRM2 | |
| SCHEMBL12232285 | 0.90 | ADAMTS5 (0.44) | MMP2ADAMTS5RAB9AENPP2GAA | |
| SCHEMBL12232520 | 0.88 | CHRM2 (0.48) | MMP2ADAMTS5CHRM2CHRM5CHRM1 | |
| SCHEMBL12232280 | 0.88 | KMT2A (0.48) | MMP2ADAMTS5MMP13ACHEMAPT | |
| SCHEMBL12232680 | 0.87 | ADAMTS5 (0.49) | MMP2ADAMTS5 | |
| SCHEMBL12232288 | 0.86 | HTR1A (0.43) | RAB9AGAAACHEMAPTHPGD | |
| SCHEMBL12232282 | 0.85 | MMP2 (0.42) | MMP2ADAMTS5 | |
| SCHEMBL12233005 | 0.82 | MAPT (0.54) | GAAMAPTHPGDTP53SMN1; SMN2 | |
| SCHEMBL12233864 | 0.82 | MMP2 (0.47) | MMP2ADAMTS5MMP13RAB9AGAA | |
| SCHEMBL12232950 | 0.81 | MMP2 (0.49) | MMP2ADAMTS5ACHEGRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110251212-A1 | PIPERAZINE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2011-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251212-A1 | PIPERAZINE DERIVATIVES | GRIN2C, NR2C2, GRIN3A | MMP2 4094/4885ADAMTS5 4846/4885MMP13 4672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.