Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 3/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | TACR2 | P21452 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SHBG | P04278 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL239040 | 0.87 | CA2 (0.60) | CA2CYP4A11LTA4HEPHX2PPARA | |
| SCHEMBL12235091 | 0.84 | CA2 (0.59) | CA2CYP4A11PPARACYP4F2TDP1 | |
| SCHEMBL547631 | 0.84 | CA2 (0.58) | CA2CYP4A11LTA4HEPHX2PPARA | |
| SCHEMBL242247 | 0.81 | CA2 (0.62) | CA2CYP4A11LTA4HEPHX2PPARA | |
| SCHEMBL332100 | 0.81 | GFER (0.42) | CA2ESR1ESR2SLC6A2ADRA2A | |
| SCHEMBL6034023 | 0.80 | CA2 (0.50) | CA2CYP4A11LTA4HEPHX2PPARA | |
| SCHEMBL22611850 | 0.80 | CA2 (0.50) | CA2CYP4A11LTA4HEPHX2PPARA | |
| SCHEMBL2329516 | 0.79 | CA2 (0.54) | CA2CYP4A11LTA4HEPHX2PPARA | |
| SCHEMBL3535251 | 0.79 | CA2 (0.54) | CA2CYP4A11LTA4HEPHX2PPARA | |
| SCHEMBL242504 | 0.78 | CA2 (0.61) | CA2CYP4A11LTA4HEPHX2CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2279291-B1 | COFERONS AND METHODS OF MAKING AND USING THEM | UNIV CORNELL (US) | 2019-07-03 | — | — | EP | disclosed |
| US-9943603-B2 | Coferons and methods of making and using them | CORNELL UNIVERSITY (US) | 2018-04-17 | — | — | US | disclosed |
| US-9943603-B2 | Coferons and methods of making and using them | CORNELL UNIVERSITY (US) | 2018-04-17 | — | — | US | disclosed |
| US-20150105553-A1 | COFERONS AND METHODS OF MAKING AND USING THEM | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-04-16 | — | — | US | disclosed |
| US-20150105553-A1 | COFERONS AND METHODS OF MAKING AND USING THEM | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-04-16 | — | — | US | disclosed |
| US-8853185-B2 | Coferons and methods of making and using them | CORNELL UNIVERSITY (US) | 2014-10-07 | — | — | US | disclosed |
| US-8853185-B2 | Coferons and methods of making and using them | CORNELL UNIVERSITY (US) | 2014-10-07 | — | — | US | disclosed |
| US-20110263688-A1 | COFERONS AND METHODS OF MAKING AND USING THEM | PURDUE RESEARCH FOUNDATION (US) | 2011-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105553-A1 | COFERONS AND METHODS OF MAKING AND USING THEM | MYOF, TNFSF11, F13B | CA2 1318/4885CYP4A11 4632/4885LTA4H 3911/4885 |
| US-20110263688-A1 | COFERONS AND METHODS OF MAKING AND USING THEM | MYOF, FTH1, TFRC | CA2 2129/4885CYP4A11 4235/4885LTA4H 4104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.