Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.77 |
| ▸ | PKM | P14618 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13567563 | 0.86 | HSD11B1 (0.62) | KMT2APKMALDH1A1HSD11B1GAA | |
| SCHEMBL28538242 | 0.81 | HSD11B1 (0.72) | KMT2APKMRECQLHSD11B1GAA | |
| SCHEMBL4528141 | 0.81 | KMT2A (0.65) | KMT2APKMALDH1A1POLBGAA | |
| SCHEMBL30209484 | 0.80 | RECQL (0.68) | KMT2APKMALDH1A1RECQLHSD11B1 | |
| SCHEMBL28427382 | 0.80 | RECQL (0.68) | KMT2APKMALDH1A1RECQLHSD11B1 | |
| SCHEMBL2422002 | 0.78 | RECQL (1.00) | KMT2APKMALDH1A1RECQLHSD11B1 | |
| SCHEMBL28538245 | 0.77 | HSD11B1 (0.91) | PKMALDH1A1RECQLHSD11B1POLB | |
| SCHEMBL30209485 | 0.77 | HSD11B1 (0.80) | KMT2APKMALDH1A1RECQLHSD11B1 | |
| SCHEMBL29609963 | 0.77 | RECQL (0.97) | KMT2APKMALDH1A1RECQLHSD11B1 | |
| SCHEMBL29012562 | 0.76 | HSD11B1 (0.83) | KMT2APKMALDH1A1RECQLHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9387254-B2 | Prodrugs and drug-macromolecule conjugates having controlled drug release rates | PROLYNX LLC (US) | 2016-07-12 | — | — | US | disclosed |
| US-20140296476-A1 | PRODRUGS AND DRUG-MACROMOLECULE CONJUGATES HAVING CONTROLLED DRUG RELEASE RATES | PROLYNX LLC | 2014-10-02 | — | — | US | disclosed |
| US-8680315-B2 | Prodrugs and drug-macromolecule conjugates having controlled drug release rates | PROLYNX, LLC (US) | 2014-03-25 | — | — | US | disclosed |
| US-20110263502-A1 | PRODRUGS AND DRUG-MACROMOLECULE CONJUGATES HAVING CONTROLLED DRUG RELEASE RATES | PROLYNX, LLC | 2011-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296476-A1 | PRODRUGS AND DRUG-MACROMOLECULE CONJUGATES HAVING CONTROLLED DRUG RELEASE RATES | ABCB1, ABCB11, DNPEP | KMT2A 3824/4885PKM 622/4885ALDH1A1 701/4885 |
| US-20110263502-A1 | PRODRUGS AND DRUG-MACROMOLECULE CONJUGATES HAVING CONTROLLED DRUG RELEASE RATES | ABCB1, ABCB11, DNPEP | KMT2A 3824/4885PKM 622/4885ALDH1A1 701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.