Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | IGF1R | P08069 | 5/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13353680 | 0.93 | EPHX2 (0.36) | ALDH1A1LMNAFAAHOPRD1OPRK1 | |
| SCHEMBL12239057 | 0.93 | HDAC3 (0.38) | ALDH1A1LMNAFAAHIGF1RHDAC3 | |
| SCHEMBL14553746 | 0.93 | ALDH1A1 (0.39) | ALDH1A1LMNAFAAHCYP2D6OPRD1 | |
| SCHEMBL1684555 | 0.93 | ALDH1A1 (0.39) | ALDH1A1LMNAFAAHCYP2D6OPRD1 | |
| SCHEMBL12238793 | 0.88 | ALDH1A1 (0.37) | ALDH1A1LMNACYP2D6EPHX2 | |
| SCHEMBL12239041 | 0.86 | TPSAB1 (0.35) | ALDH1A1LMNAOPRD1OPRK1EPHX2 | |
| SCHEMBL14553761 | 0.86 | EPHX2 (0.36) | ALDH1A1LMNAFAAHCYP2D6OPRD1 | |
| SCHEMBL14553751 | 0.86 | FAAH (0.36) | ALDH1A1LMNAFAAHOPRK1IGF1R | |
| SCHEMBL19392801 | 0.86 | ALDH1A1 (0.39) | ALDH1A1LMNAFAAHCYP2D6OPRD1 | |
| SCHEMBL1684887 | 0.85 | FAAH (0.36) | FAAHOPRD1OPRK1IGF1RHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039472-B2 | Pyrazine-2-carboxamide derivatives to treat diseases mediated by blockade of the epithelial sodium channel | NOVARTIS AG (CH) | 2011-10-18 | — | — | US | disclosed |
| US-20100130506-A1 | Organic Compounds | NOVARTIS AG | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130506-A1 | Organic Compounds | OR10J3, REN, CACNA1E | ALDH1A1 1317/4885LMNA 2001/4885FAAH 4378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.