SCHEMBL12247713

SCHEMBL12247713

O=C(N[C@@H](CCCCNC(=O)C(F)(F)F)C(=O)O)OCc1ccccc1

nearest known ligand 0.63

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ FOLH1 Q04609 3/20 0.63
▸ TGM2 P21980 10/20 0.62
▸ SIRT2 Q8IXJ6 2/20 0.62
▸ SIRT1 Q96EB6 2/20 0.62
▸ ITGB3 P05106 2/20 0.58
▸ ITGAV P06756 2/20 0.58
▸ SIRT5 Q9NXA8 1/20 0.55
▸ MMP2 P08253 1/20 0.54
▸ MMP9 P14780 1/20 0.54
▸ SIRT3 Q9NTG7 1/20 0.53
▸ CPB1 P15086 1/20 0.53
▸ CPB2 Q96IY4 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4539252 0.91 FOLH1 (0.69) FOLH1TGM2SIRT2SIRT1MMP2
SCHEMBL806151 0.88 FOLH1 (0.78) FOLH1TGM2SIRT2SIRT1ITGB3
SCHEMBL464715 0.88 FOLH1 (0.78) FOLH1TGM2SIRT2SIRT1ITGB3
SCHEMBL4561005 0.88 FOLH1 (0.78) FOLH1TGM2SIRT2SIRT1ITGB3
SCHEMBL5841119 0.86 FOLH1 (0.68) FOLH1TGM2SIRT2SIRT1ITGB3
SCHEMBL8387978 0.85 FOLH1 (0.65) FOLH1TGM2SIRT2SIRT1ITGB3
SCHEMBL27429289 0.85 SIRT2 (0.69) FOLH1TGM2SIRT2SIRT1ITGB3
SCHEMBL5841123 0.85 FOLH1 (0.67) FOLH1TGM2SIRT2SIRT1ITGB3
SCHEMBL4173691 0.84 FOLH1 (0.72) FOLH1TGM2SIRT2SIRT1ITGB3
SCHEMBL4173693 0.84 FOLH1 (0.72) FOLH1TGM2SIRT2SIRT1ITGB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4425181-A1 COMPOSITION FOR DETECTING OR MEASURING ANALYTE Bertis Inc (KR) 2024-09-04 — — EP disclosed
US-11965889-B2 Lysine monomethylated derivative and corresponding antibody and use thereof PMT BIOLABS INC (CN) 2024-04-23 — — US disclosed
US-20240011979-A1 COMPOSITION FOR DETECTING OR MEASURING ANALYTES BERTIS INC. (KR) 2024-01-11 — — US disclosed
CN-116829949-A Compositions for detecting or measuring analytes 伯蒂斯有限公司 2023-09-29 — — CN disclosed
WO-2023075435-A1 COMPOSITION FOR DETECTING OR MEASURING ANALYTE 주식회사 베르티스 2023-05-04 — — WO disclosed
US-20220283131-A1 COMPOSITION FOR DETECTING OR MEASURING ANALYTES BERTIS CO., LTD. (KR) 2022-09-08 — — US disclosed
CN-105273060-B Lysine single methylation derivatization modified antibody and preparation method thereof 杭州景杰生物科技股份有限公司 2022-07-19 — — CN disclosed
WO-2022050529-A1 COMPOSITION FOR DETECTING OR MEASURING ANALYTE ㈜베르티스 2022-03-10 — — WO disclosed
US-8338469-B2 Compounds and compositions as channel activating protease inhibitors IRM LLC (BM) 2012-12-25 — — US disclosed
US-20110257077-A1 COMPOUNDS AND COMPOSITIONS AS CHANNEL ACTIVATING PROTEASE INHIBITORS IRM LLC (BM) 2011-10-20 — — US disclosed
US-7951823-B2 Compounds and compositions as channel activating protease inhibitors IRM LLC (BM) 2011-05-31 — — US disclosed
US-20070275906-A1 Compounds and Compositions as Channel Activating Protease Inhibitors IRM LLC (BM) 2007-11-29 — — US disclosed
US-20070275906-A1 Compounds and Compositions as Channel Activating Protease Inhibitors IRM LLC (BM) 2007-11-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11965889-B2 Lysine monomethylated derivative and corresponding antibody and use thereof KMT5A, PTMS, KDM4D FOLH1 1805/4885TGM2 1967/4885SIRT2 2020/4885
US-20110257077-A1 COMPOUNDS AND COMPOSITIONS AS CHANNEL ACTIVATING PROTEASE INHIBITORS PRSS1, PRSS8, PRSS2 FOLH1 1818/4885TGM2 2442/4885SIRT2 930/4885
US-20070275906-A1 Compounds and Compositions as Channel Activating Protease Inhibitors PRSS1, PRSS8, PRSS2 FOLH1 1818/4885TGM2 2442/4885SIRT2 930/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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