Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 9/20 | 0.33 |
| ▸ | BCL9 | O00512 | 3/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | PTGES | O14684 | 2/20 | 0.33 |
| ▸ | PNLIP | P16233 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12249334 | 0.79 | CYP19A1 (0.43) | USP2CYP3A4MAPTMEN1KMT2A | |
| SCHEMBL12249340 | 0.74 | FDPS (0.48) | USP2CYP3A4MAPTMEN1KMT2A | |
| SCHEMBL22861906 | 0.65 | EP300 (0.40) | USP2CYP3A4MAPTMEN1KMT2A | |
| SCHEMBL21291523 | 0.65 | EP300 (0.40) | USP2CYP3A4MAPTMEN1KMT2A | |
| SCHEMBL22862032 | 0.65 | EP300 (0.40) | USP2CYP3A4MAPTMEN1KMT2A | |
| SCHEMBL21291508 | 0.65 | EP300 (0.40) | USP2CYP3A4MAPTMEN1KMT2A | |
| SCHEMBL18290368 | 0.65 | FDPS (0.43) | USP2CYP3A4MAPTMEN1KMT2A | |
| SCHEMBL18290309 | 0.60 | FDPS (0.49) | USP2CYP3A4MAPTMEN1KMT2A | |
| 6-Alpha-Hydroxydemethyl-Cryptojaponol SCHEMBL18290237 | 0.60 | SOD1 (0.54) | USP2CYP3A4MAPTMEN1KMT2A | |
| SCHEMBL18290361 | 0.60 | FDPS (0.49) | USP2CYP3A4MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8466311-B2 | Neuroprotective compositions and methods | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2013-06-18 | — | — | US | disclosed |
| US-20120296112-A1 | Neuroprotective Compositions and Methods | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-11-22 | — | — | US | disclosed |
| US-8022246-B2 | Neuroprotective compositions and methods | THE BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2011-09-20 | — | — | US | disclosed |
| US-20090042980-A1 | Neuroprotective compositions and methods | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042980-A1 | Neuroprotective compositions and methods | KEAP1, NFE2L2, NQO1 | USP2 2063/4885CYP3A4 4206/4885MAPT 506/4885 |
| US-20120296112-A1 | Neuroprotective Compositions and Methods | KEAP1, NFE2L2, NQO1 | USP2 2063/4885CYP3A4 4206/4885MAPT 506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.