Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14954978 | 0.89 | TLR4 (0.36) | MAPTHIF1ACNR2ALDH1A1KMT2A | |
| SCHEMBL12539313 | 0.81 | MEN1 (0.38) | CNR2ALDH1A1TRPA1PKMKDM4E | |
| SCHEMBL7219547 | 0.80 | THRA (0.35) | CNR2ALDH1A1THRBTHRA | |
| SCHEMBL15468393 | 0.80 | ALDH1A1 (0.34) | MAPTHIF1AALDH1A1KDM4ETHRB | |
| SCHEMBL7490833 | 0.80 | HPGD (0.44) | ALDH1A1PKMKDM4EMEN1KMT2A | |
| SCHEMBL16369938 | 0.78 | CYP4F2 (0.38) | MAPTHIF1AALDH1A1PKMKDM4E | |
| SCHEMBL30326594 | 0.78 | MMP8 (0.43) | CNR2ALDH1A1PKMKDM4EMEN1 | |
| SCHEMBL1226275 | 0.77 | THRA (0.38) | MAPTALDH1A1THRBLMNAPOLB | |
| SCHEMBL15468407 | 0.77 | ALDH1A1 (0.40) | MAPTHIF1AALDH1A1KDM4EMEN1 | |
| SCHEMBL9418568 | 0.75 | ALDH1A1 (0.44) | MAPTHIF1AALDH1A1TRPA1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324417-B2 | Process for the preparation of (S)-2-amino-5-cyclopropyl-4,4-difluoropentanoic acid and alkyl esters and acid salts thereof | VIROBAY, INC. (US) | 2012-12-04 | — | — | US | claimed |
| WO-2011022429-A2 | PROCESS FOR THE PREPARATION OF (S)-2-AMINO-5-CYCLOPROPYL-4,4-DIFLUOROPENTANOIC ACID AND ALKYL ESTERS AND ACID SALTS THEREOF | VIROBAY, INC. (US) | 2011-02-24 | — | — | WO | claimed |
| US-20110046406-A1 | PROCESS FOR THE PREPARATION OF (S)-2-AMINO-5-CYCLOPROPYL-4,4-DIFLUOROPENTANOIC ACID AND ALKYL ESTERS AND ACID SALTS THEREOF | VIROBAY, INC. (US) | 2011-02-24 | — | — | US | claimed |
| US-8324417-B2 | Process for the preparation of (S)-2-amino-5-cyclopropyl-4,4-difluoropentanoic acid and alkyl esters and acid salts thereof | VIROBAY, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-8324417-B2 | Process for the preparation of (S)-2-amino-5-cyclopropyl-4,4-difluoropentanoic acid and alkyl esters and acid salts thereof | VIROBAY, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-8324417-B2 | Process for the preparation of (S)-2-amino-5-cyclopropyl-4,4-difluoropentanoic acid and alkyl esters and acid salts thereof | VIROBAY, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| WO-2011022429-A2 | PROCESS FOR THE PREPARATION OF (S)-2-AMINO-5-CYCLOPROPYL-4,4-DIFLUOROPENTANOIC ACID AND ALKYL ESTERS AND ACID SALTS THEREOF | VIROBAY, INC. (US) | 2011-02-24 | — | — | WO | disclosed |
| WO-2011022429-A2 | PROCESS FOR THE PREPARATION OF (S)-2-AMINO-5-CYCLOPROPYL-4,4-DIFLUOROPENTANOIC ACID AND ALKYL ESTERS AND ACID SALTS THEREOF | VIROBAY, INC. (US) | 2011-02-24 | — | — | WO | disclosed |
| US-20110046406-A1 | PROCESS FOR THE PREPARATION OF (S)-2-AMINO-5-CYCLOPROPYL-4,4-DIFLUOROPENTANOIC ACID AND ALKYL ESTERS AND ACID SALTS THEREOF | VIROBAY, INC. (US) | 2011-02-24 | — | — | US | disclosed |
| US-20110046406-A1 | PROCESS FOR THE PREPARATION OF (S)-2-AMINO-5-CYCLOPROPYL-4,4-DIFLUOROPENTANOIC ACID AND ALKYL ESTERS AND ACID SALTS THEREOF | VIROBAY, INC. (US) | 2011-02-24 | — | — | US | disclosed |
| US-20110046406-A1 | PROCESS FOR THE PREPARATION OF (S)-2-AMINO-5-CYCLOPROPYL-4,4-DIFLUOROPENTANOIC ACID AND ALKYL ESTERS AND ACID SALTS THEREOF | VIROBAY, INC. (US) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046406-A1 | PROCESS FOR THE PREPARATION OF (S)-2-AMINO-5-CYCLOPROPYL-4,4-DIFLUOROPENTANOIC ACID AND ALKYL ESTERS AND ACID SALTS THEREOF | DNPEP, CTRL, CTSS | MAPT 3709/4885HIF1A 3582/4885CNR2 2062/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.