Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRHR | P34981 | 6/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14468463 | 0.85 | L3MBTL1 (0.42) | TRHRHDAC3HDAC1HDAC10HDAC11 | |
| SCHEMBL12228303 | 0.84 | TRHR (0.56) | TRHR | |
| SCHEMBL8258114 | 0.82 | TRHR (0.47) | TRHR | |
| SCHEMBL8260031 | 0.75 | TRHR (0.55) | TRHR | |
| SCHEMBL14185774 | 0.74 | TRHR (0.55) | TRHR | |
| SCHEMBL12228300 | 0.74 | TRHR (0.57) | TRHR | |
| SCHEMBL14543240 | 0.73 | TRHR (0.40) | TRHRHDAC3HDAC1HDAC10HDAC11 | |
| SCHEMBL8251458 | 0.73 | TRHR (0.50) | TRHR | |
| SCHEMBL8252513 | 0.73 | TRHR (0.78) | TRHR | |
| SCHEMBL8256591 | 0.73 | TRHR (0.59) | TRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044103-B2 | Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders | GEORGETOWN UNIVERSITY (US) | 2011-10-25 | — | — | US | disclosed |