Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPI | P34949 | 15/20 | 1.00 |
| ▸ | PMM2 | O15305 | 13/20 | 1.00 |
| ▸ | PHOSPHO1 | Q8TCT1 | 13/20 | 1.00 |
| ▸ | RAB9A | P51151 | 3/20 | 1.00 |
| ▸ | APOBEC3G | Q9HC16 | 4/20 | 0.72 |
| ▸ | IDE | P14735 | 1/20 | 0.72 |
| ▸ | G6PD | P11413 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | PKM | P14618 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.56 |
| ▸ | CASP3 | P42574 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | EP300 | Q09472 | 1/20 | 0.56 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.56 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17515275 | 0.85 | MPI (0.78) | MPIPMM2PHOSPHO1RAB9AAPOBEC3G | |
| SCHEMBL1899594 | 0.85 | MPI (0.74) | MPIPMM2PHOSPHO1RAB9AAPOBEC3G | |
| SCHEMBL6883780 | 0.80 | MPI (0.67) | MPIPMM2PHOSPHO1RAB9AAPOBEC3G | |
| SCHEMBL2538424 | 0.80 | MPI (1.00) | MPIPMM2PHOSPHO1RAB9AAPOBEC3G | |
| SCHEMBL29530129 | 0.79 | MPI (0.65) | MPIPMM2PHOSPHO1RAB9AAPOBEC3G | |
| SCHEMBL1896513 | 0.79 | MPI (0.65) | MPIPMM2PHOSPHO1RAB9AAPOBEC3G | |
| SCHEMBL1901601 | 0.79 | MPI (0.65) | MPIPMM2PHOSPHO1RAB9AAPOBEC3G | |
| SCHEMBL2413025 | 0.76 | MPI (1.00) | MPIPMM2PHOSPHO1RAB9AAPOBEC3G | |
| SCHEMBL8371855 | 0.76 | MPI (0.68) | MPIPMM2PHOSPHO1RAB9AAPOBEC3G | |
| SCHEMBL1899155 | 0.75 | MPI (0.60) | MPIPMM2PHOSPHO1RAB9AAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170136030-A1 | TREATMENT OF MALARIA USING INHIBITORS OF THE ISPD ENZYME IN THE NON-MEVALONATE PATHWAY | WASHINGTON UNIVERSITY (US) | 2017-05-18 | — | — | US | disclosed |
| US-20170136030-A1 | TREATMENT OF MALARIA USING INHIBITORS OF THE ISPD ENZYME IN THE NON-MEVALONATE PATHWAY | WASHINGTON UNIVERSITY (US) | 2017-05-18 | — | — | US | disclosed |
| US-20170136030-A1 | TREATMENT OF MALARIA USING INHIBITORS OF THE ISPD ENZYME IN THE NON-MEVALONATE PATHWAY | WASHINGTON UNIVERSITY (US) | 2017-05-18 | — | — | US | disclosed |
| US-20160046651-A1 | TREATMENT OF MALARIA USING INHIBITORS OF THE ISPD ENZYME IN THE NON-MEVALONATE PATHWAY | UNIV WASHINGTON (US) | 2016-02-18 | — | — | US | disclosed |
| US-20160046651-A1 | TREATMENT OF MALARIA USING INHIBITORS OF THE ISPD ENZYME IN THE NON-MEVALONATE PATHWAY | UNIV WASHINGTON (US) | 2016-02-18 | — | — | US | disclosed |
| US-20160046651-A1 | TREATMENT OF MALARIA USING INHIBITORS OF THE ISPD ENZYME IN THE NON-MEVALONATE PATHWAY | UNIV WASHINGTON (US) | 2016-02-18 | — | — | US | disclosed |
| US-20110257233-A1 | BENZOISOTHIAZOLONES AS INHIBITORS OF PHOSPHOMANNOSE ISOMERASE | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-10-20 | — | — | US | disclosed |
| WO-2011116355-A2 | BENZOISOTHIAZOLONES AS INHIBITORS OF PHOSPHOMANNOSE ISOMERASE | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160046651-A1 | TREATMENT OF MALARIA USING INHIBITORS OF THE ISPD ENZYME IN THE NON-MEVALONATE PATHWAY | IMPDH1, IMPDH2, SHMT2 | MPI 10/4885PMM2 146/4885PHOSPHO1 342/4885 |
| US-20170136030-A1 | TREATMENT OF MALARIA USING INHIBITORS OF THE ISPD ENZYME IN THE NON-MEVALONATE PATHWAY | IMPDH1, IMPDH2, SHMT2 | MPI 10/4885PMM2 146/4885PHOSPHO1 342/4885 |
| US-20110257233-A1 | BENZOISOTHIAZOLONES AS INHIBITORS OF PHOSPHOMANNOSE ISOMERASE | MPI, PMM2, GPI | MPI 1/4885PMM2 2/4885PHOSPHO1 2200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.