SCHEMBL12254866

SCHEMBL12254866

O=C(O)CCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O

nearest known ligand 0.60

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.58
MDM4 O15151 2/20 0.58
TP53 P04637 2/20 0.58
TLR2 O60603 2/20 0.57
CASP3 P42574 2/20 0.55
MDM2 Q00987 5/20 0.54
PTPN1 P18031 2/20 0.52
SLC17A5 Q9NRA2 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29354378 1.00 KMT2A (0.58) KMT2AMDM4TP53TLR2CASP3
SCHEMBL30338216 1.00 KMT2A (0.58) KMT2AMDM4TP53TLR2CASP3
SCHEMBL29908078 1.00 KMT2A (0.58) KMT2AMDM4TP53TLR2CASP3
SCHEMBL29400089 1.00 KMT2A (0.58) KMT2AMDM4TP53TLR2CASP3
SCHEMBL1025352 1.00 KMT2A (0.58) KMT2AMDM4TP53TLR2CASP3
SCHEMBL14997839 1.00 KMT2A (0.58) KMT2AMDM4TP53TLR2CASP3
SCHEMBL12658035 0.95 PTPN1 (0.58) KMT2AMDM4TP53TLR2CASP3
SCHEMBL14719947 0.93 KMT2A (0.57) KMT2AMDM4TP53TLR2CASP3
SCHEMBL22712859 0.93 TLR2 (0.54) KMT2AMDM4TP53TLR2CASP3
D-Glutamate SCHEMBL28574794 0.93 MDM4 (0.52) KMT2AMDM4TP53TLR2CASP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118005719-A SIRP alpha blocker polypeptide, construction method and application thereof 华东理工大学 2024-05-10 CN claimed
CN-115340472-B Glutamic acid derivative and synthesis method and application thereof 合肥工业大学 2024-05-07 CN claimed
CN-117224690-B Gamma-polyglutamic acid mixture, composition and preparation method as auxiliary agent 江苏海王健康生物科技有限公司 2024-01-30 CN claimed
CN-115844790-A Hair conditioner and preparation method thereof 北京普世安生物科技有限公司 2023-03-28 CN claimed
CN-120053682-A Multi-drug linked combination drug conjugate and application thereof 上海睿智医药研究集团有限公司 2025-05-30 CN disclosed
EP-4469468-A1 PROCESS FOR THE PREPARATION OF LINACLOTIDE Fresenius Kabi iPSUM S.r.l. (IT) 2024-12-04 EP disclosed
CN-118256591-A Cyclic peptide compound having high membrane permeability and library comprising same 中外制药株式会社 2024-06-28 CN disclosed
US-12018093-B2 Hemiasterlin derivatives and antibody-drug conjugates including same Sumitomo Pharma Co., Ltd. (JP) 2024-06-25 US disclosed
CN-118063551-A Polypeptide with pH response antibacterial and enzyme response antioxidant functions and application thereof 郑州大学 2024-05-24 CN disclosed
WO-2024097320-A1 AZOTOMYCIN PRODRUGS WITH PREFERENTIAL TUMOR DELIVERY THE JOHNS HOPKINS UNIVERSITY (US) 2024-05-10 WO disclosed
CN-118005719-A SIRP alpha blocker polypeptide, construction method and application thereof 华东理工大学 2024-05-10 CN disclosed
CN-115340472-B Glutamic acid derivative and synthesis method and application thereof 合肥工业大学 2024-05-07 CN disclosed
CN-102149411-A Method for acylating a peptide or protein NOVO NORDISK AS 2011-08-10 CN disclosed
EP-1961764-B1 SUGAR CHAIN ADDUCT OF PEPTIDE AND PHARMACEUTICAL COMPRISING THE SAME AS ACTIVE INGREDIENT SHIONOGI & CO (JP) 2011-05-11 EP disclosed
US-20100016547-A1 Glycosilated Peptide and Medicine Comprising It as an Effective Ingredient NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (JP) 2010-01-21 US disclosed
US-20100016547-A1 Glycosilated Peptide and Medicine Comprising It as an Effective Ingredient NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (JP) 2010-01-21 US disclosed
CN-101434645-A Synthetic oligopeptide and uses thereof UNIV CHINA AGRICULTURAL (CN) 2009-05-20 CN disclosed
US-20080207625-A1 Synthesis and Purification of Pteroic Acid and Conjugates Thereof ENDOCYTE, INC. (US) 2008-08-28 US disclosed
EP-1961764-A1 SUGAR CHAIN ADDUCT OF PEPTIDE AND PHARMACEUTICAL COMPRISING THE SAME AS ACTIVE INGREDIENT Shionogi Co., Ltd. (JP) 2008-08-27 EP disclosed
US-7220414-B2 Degradable polyacetal polymers A.P. PHARMA, INC. (US) 2007-05-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100016547-A1 Glycosilated Peptide and Medicine Comprising It as an Effective Ingredient GLP1R, VIP, IAPP KMT2A 2957/4885MDM4 4750/4885TP53 4366/4885
US-20080207625-A1 Synthesis and Purification of Pteroic Acid and Conjugates Thereof DHFR, SLC46A1, FOLR1 KMT2A 1493/4885MDM4 2643/4885TP53 1577/4885
US-12018093-B2 Hemiasterlin derivatives and antibody-drug conjugates including same FCGRT, QARS1, INHA KMT2A 496/4885MDM4 2717/4885TP53 1516/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.