Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tolonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APAF1 | O14727 | 1/20 | 0.64 |
| ▸ | TERT | O14746 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 5/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tolonium SCHEMBL30495506 | 1.00 | APAF1 (0.64) | APAF1TERTAPPEGFRPDE3B | |
| Tolonium SCHEMBL2626791 | 0.99 | APAF1 (0.66) | APAF1TERTAPPEGFRPDE3B | |
| Methylene Blue Cation SCHEMBL1351 | 0.84 | APP (0.55) | APAF1TERTAPPEGFRPDE3B | |
| Methylene Blue Cation SCHEMBL4565666 | 0.84 | APP (0.55) | APAF1TERTAPPEGFRPDE3B | |
| Methylene Blue Cation SCHEMBL29474195 | 0.84 | APP (0.55) | APAF1TERTAPPEGFRPDE3B | |
| Methylene Blue Cation SCHEMBL1462448 | 0.83 | APP (0.53) | APAF1TERTAPPEGFRPDE3B | |
| Methylene Blue Cation SCHEMBL1535732 | 0.83 | APP (0.53) | APAF1TERTAPPEGFRPDE3B | |
| Methylene Blue Cation SCHEMBL31038651 | 0.83 | APP (0.53) | APAF1TERTAPPEGFRPDE3B | |
| Methylene Blue Cation SCHEMBL1535728 | 0.83 | APP (0.53) | APAF1TERTAPPEGFRPDE3B | |
| Methylene Blue Cation SCHEMBL1207311 | 0.83 | APP (0.53) | APAF1TERTAPPEGFRPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 8546 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122076396-A | Multifunctional aerogel film based on charge demulsification, preparation method and application | — | 2026-05-26 | — | — | CN | claimed |
| CN-122051298-A | Water system organic flow battery | 中国科学院大连化学物理研究所 | 2026-05-15 | — | — | CN | claimed |
| WO-2026088160-A1 | IMPROVED ELECTROCHEMICAL BIOSENSORS | ARMA BIOSCIENCES (CA) | 2026-04-30 | — | — | WO | claimed |
| EP-4655582-B1 | METHOD FOR DETECTING AND/OR QUANTIFYING, IN A SAMPLE OF BLOOD OR DERIVATE BIOLOGICAL LIQUID, A PANEL OF HAEMATOLOGICAL PARAMETERS | FIDELIO MEDICAL S R L (IT) | 2026-04-29 | — | — | EP | claimed |
| EP-4732029-A1 | METHODS FOR MAGNETIC RESONANCE MOLECULAR IMAGING OF NANOCONSTRUCTS AND USES THEREOF | Regents of the University of Michigan (US) | 2026-04-29 | — | — | EP | claimed |
| EP-4719328-A1 | BLEACHING MEDIUM COMPRISING A PHENALENONE | Wella Germany GmbH (DE) | 2026-04-08 | — | — | EP | claimed |
| US-20260092333-A1 | METHOD FOR EVALUATING SEEDLING PLANT CHARACTER OF TRANSGENIC POPLAR AND USE OF OVEREXPRESSED PAGEXPA1 GENE IN PROMOTING XYLEM DEVELOPMENT OF POPLAR | RESEARCH INSTITUTE OF FORESTRY, CHINESE ACADEMY OF FORESTRY (CN) | 2026-04-02 | — | — | US | claimed |
| EP-4713293-A1 | METAL NANOPARTICLES STABILIZED WITH CATIONIC COMPOUNDS CAPABLE OF ABSORBING VISIBLE LIGHT | Fundació Eurecat (ES) | 2026-03-25 | — | — | EP | claimed |
| US-20260072020-A1 | PRINTABLE MOLECULE-SELECTIVE CORE-SHELL NANOPARTICLES FOR WEARABLE AND IMPLANTABLE SENSING | CALIFORNIA INST OF TECHN (US) | 2026-03-12 | — | — | US | claimed |
| US-12569371-B2 | Sterilization of medical dressings with enhanced antimicrobial properties | HYDROFERA, LLC (US) | 2026-03-10 | — | — | US | claimed |
| EP-0383126-A2 | Photopolymerization diagnostic test composition and method for immunoassay and nucleic acid assay | OSTER, Gerald (US) | 1990-08-22 | — | — | EP | claimed |
| EP-0094398-B1 | DYESTUFF COMPOSITION FOR HISTOLOGICAL EXAMINATIONS | REANAL FINOMVEGYSZERGYAR (HU) | 1986-10-29 | — | — | EP | claimed |
| EP-0062177-B1 | DYEING SOLUTION CONTAINING A THIAZINE DYE, AND PROCESS FOR PREPARING THE SAME | MERCK PATENT GmbH (DE) | 1986-10-08 | — | — | EP | claimed |
| US-4548927-A | Method and agents for raising animal tolerance to oxidant stress-inducing antibiotics | EATON JOHN W (US) | 1985-10-22 | — | — | US | claimed |
| US-4481291-A | Process for determining streptococcal desoxyribonuclease B according to the toluidine blue O method | BEHRINGWERKE AKTIENGESELLSCHAFT (DE) | 1984-11-06 | — | — | US | claimed |
| US-4345470-A | All plastic disposable thermometer | AKZONA INCORPORATED (US) | 1982-08-24 | — | — | US | claimed |
| US-4299727-A | Disposable reversible thermometer | AKZONA INCORPORATED (US) | 1981-11-10 | — | — | US | claimed |
| US-4247541-A | CULTURE PRODUCT EFFECTIVE FOR INTERFERON PRODUCTION | KIRIN BREWERY COMPANY LIMITED (JP) | 1981-01-27 | — | — | US | claimed |
| US-4232552-A | THERMOCHROMISM, DISPOSABLE THERMOMETERS | AKZONA INCORPORATED (US) | 1980-11-11 | — | — | US | claimed |
| US-3990946-A | Substrate for the determination of desoxy-ribonuclease | BEHRINGWERKE AKTIENGESELLSCHAFT (DT) | 1976-11-09 | — | — | US | claimed |