Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.34 |
| ▸ | CLK1 | P49759 | 4/20 | 0.34 |
| ▸ | CLK2 | P49760 | 3/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
| ▸ | CLK3 | P49761 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10179244 | 0.82 | CDK9 (0.40) | MTORMAP4K4MINK1TNIKDYRK1A | |
| SCHEMBL10179605 | 0.72 | CCNT1 (0.39) | DYRK1BCCNT1 | |
| SCHEMBL1462894 | 0.72 | CCNT1 (0.45) | DYRK1BCCNT1 | |
| SCHEMBL15378088 | 0.72 | CDK9 (0.42) | MTORDYRK1ACLK4CLK1CLK2 | |
| SCHEMBL12465812 | 0.72 | CDK9 (0.35) | MTORMAP4K4MINK1TNIKDYRK1B | |
| SCHEMBL1462859 | 0.70 | RORC (0.32) | — | |
| SCHEMBL1191911 | 0.70 | CCNT1 (0.49) | DYRK1BCCNT1 | |
| SCHEMBL1462906 | 0.69 | CCNT1 (0.45) | ADORA2BGRM2MAPK1CCNT1SYK | |
| SCHEMBL12501653 | 0.69 | ADORA2B (0.32) | ADORA2BGRM2MAPK1CCNT1ADORA2A | |
| SCHEMBL1462988 | 0.67 | CCNT1 (0.48) | DYRK1BCCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459535-A1 | PYRIDINE AND PYRAZINE DERIVATIVES AS PROTEIN KINASE MODULATORS | Novartis AG (CH) | 2012-06-06 | — | — | EP | disclosed |
| WO-2011012661-A1 | PYRIDINE AND PYRAZINE DERIVATIVES AS PROTEIN KINASE MODULATORS | NOVARTIS AG (CH) | 2011-02-03 | — | — | WO | disclosed |