Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12263309 | 0.76 | MEN1 (0.47) | MEN1KMT2ADRD2DRD3GRM2 | |
| SCHEMBL22041563 | 0.76 | CRHBP (0.48) | MEN1KMT2ALMNAGAA | |
| SCHEMBL30475796 | 0.76 | CRHBP (0.48) | MEN1KMT2ALMNAGAA | |
| SCHEMBL22623697 | 0.75 | LMNA (0.50) | CYP11B2MEN1KMT2ARAB9AFPR2 | |
| SCHEMBL2547146 | 0.74 | CYP11B2 (0.50) | CYP11B2MAPK8MAPK9MAPK10MAPK14 | |
| SCHEMBL2510621 | 0.74 | CYP11B2 (0.50) | CYP11B2MAPK8MAPK9MAPK10MAPK14 | |
| SCHEMBL23946257 | 0.71 | CYP11B2 (0.58) | CYP11B2CYP11B1 | |
| SCHEMBL16597162 | 0.70 | HSP90AB1 (0.49) | MEN1KMT2AHSP90AB1LMNA | |
| SCHEMBL16597163 | 0.70 | CRHBP (0.45) | — | |
| SCHEMBL20338285 | 0.69 | CYP11B2 (1.00) | CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123751-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2011-10-06 | — | — | WO | disclosed |