Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 12/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.61 |
| ▸ | MEN1 | O00255 | 6/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | PKM | P14618 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.60 |
| ▸ | HPGD | P15428 | 9/20 | 0.60 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL196219 | 1.00 | SMN1; SMN2 (0.62) | SMN1; SMN2TP53MAPTKDM4EMEN1 | |
| SCHEMBL196220 | 1.00 | SMN1; SMN2 (0.62) | SMN1; SMN2TP53MAPTKDM4EMEN1 | |
| SCHEMBL9455724 | 0.79 | KMT2A (0.65) | SMN1; SMN2TP53MAPTKDM4EMEN1 | |
| SCHEMBL196167 | 0.79 | SMN1; SMN2 (0.69) | SMN1; SMN2TP53MAPTKDM4EMEN1 | |
| SCHEMBL196166 | 0.79 | SMN1; SMN2 (0.69) | SMN1; SMN2TP53MAPTKDM4EMEN1 | |
| SCHEMBL12267431 | 0.79 | SMN1; SMN2 (0.69) | SMN1; SMN2TP53MAPTKDM4EMEN1 | |
| SCHEMBL8291958 | 0.77 | SMN1; SMN2 (1.00) | SMN1; SMN2TP53MAPTKDM4EMEN1 | |
| SCHEMBL13576581 | 0.75 | MMP1 (0.80) | MAPTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL9364375 | 0.73 | LPAR2 (0.63) | SMN1; SMN2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL9364381 | 0.73 | LPAR2 (0.63) | SMN1; SMN2MAPTKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9091678-B2 | Method for identifying compounds useful for treating and/or preventing disease-associated bone loss | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2015-07-28 | — | — | US | disclosed |
| US-9091678-B2 | Method for identifying compounds useful for treating and/or preventing disease-associated bone loss | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2015-07-28 | — | — | US | disclosed |
| US-20110212974-A1 | METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR TREATING AND/OR PREVENTING DISEASE-ASSOCIATED BONE LOSS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) | 2011-09-01 | — | — | US | disclosed |
| US-20110212974-A1 | METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR TREATING AND/OR PREVENTING DISEASE-ASSOCIATED BONE LOSS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212974-A1 | METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR TREATING AND/OR PREVENTING DISEASE-ASSOCIATED BONE LOSS | DOCK5, ARHGDIB, ARHGDIA | SMN1; SMN2 3196/4885TP53 3858/4885MAPT 3716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.