Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 15/20 | 0.41 |
| ▸ | REN | P00797 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 14/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11942316 | 0.84 | KCNH2 (0.44) | KCNH2RENPOLBGLO1HRH1 | |
| SCHEMBL1229758 | 0.77 | WDR5 (0.41) | POLBGLO1 | |
| SCHEMBL1071179 | 0.76 | KCNH2 (0.43) | KCNH2RENHRH1 | |
| SCHEMBL1229322 | 0.73 | REN (0.34) | KCNH2REN | |
| SCHEMBL1228551 | 0.73 | REN (0.33) | KCNH2REN | |
| SCHEMBL5847654 | 0.70 | TRPV1 (0.52) | KCNH2HRH1TRPV1 | |
| SCHEMBL1073071 | 0.70 | REN (0.56) | KCNH2RENHRH1 | |
| SCHEMBL1228546 | 0.68 | REN (0.39) | REN | |
| SCHEMBL4049830 | 0.67 | ALDH1A1 (0.46) | KCNH2POLB | |
| SCHEMBL28149455 | 0.66 | CYP1A2 (0.37) | POLBGLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120190701-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-07-26 | — | — | US | disclosed |
| WO-2011020193-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2011-02-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190701-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | KCNH2 35/4885REN 1/4885POLB 1650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.