Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 1.00 |
| ▸ | MAPK10 | P53779 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 0.63 |
| ▸ | HTT | P42858 | 4/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.60 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 10/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18292324 | 0.79 | ALDH1A1 (0.73) | ALDH1A1MAPK10LMNAHTTTSHR | |
| SCHEMBL12281815 | 0.77 | ALDH1A1 (1.00) | ALDH1A1MAPK10LMNAHTTTSHR | |
| SCHEMBL30358108 | 0.75 | ALDH1A1 (1.00) | ALDH1A1MAPK10LMNAHTTTSHR | |
| SCHEMBL19748997 | 0.75 | ALDH1A1 (1.00) | ALDH1A1MAPK10LMNAHTTTSHR | |
| SCHEMBL20228946 | 0.75 | ALDH1A1 (0.64) | ALDH1A1MAPK10LMNATSHRSMN1; SMN2 | |
| SCHEMBL18292667 | 0.74 | TP53 (0.68) | ALDH1A1MAPK10LMNAHTTTSHR | |
| SCHEMBL19746298 | 0.68 | ALDH1A1 (0.51) | ALDH1A1MAPK10LMNAHTTTSHR | |
| SCHEMBL29522912 | 0.66 | ALDH1A1 (1.00) | ALDH1A1MAPK10LMNAALDH1A2ALDH1A3 | |
| SCHEMBL30358101 | 0.66 | ALDH1A1 (1.00) | ALDH1A1MAPK10LMNAALDH1A2ALDH1A3 | |
| SCHEMBL17208552 | 0.66 | ALDH1A1 (1.00) | ALDH1A1MAPK10LMNAALDH1A2ALDH1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160354375-A1 | CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES SUCH AS TAUOPATHIES | ELECTROPHORETICS LIMITED (GB) | 2016-12-08 | — | — | US | disclosed |
| US-20130225610-A1 | ANTIMETASTATIC COMPOUNDS | HANSEN MARC (US) | 2013-08-29 | — | — | US | disclosed |
| US-20130225610-A1 | ANTIMETASTATIC COMPOUNDS | HANSEN MARC (US) | 2013-08-29 | — | — | US | disclosed |
| US-8481553-B2 | Antimetastatic compounds | BRIGHAM YOUNG UNIVERSITY (US) | 2013-07-09 | — | — | US | disclosed |
| US-8481553-B2 | Antimetastatic compounds | BRIGHAM YOUNG UNIVERSITY (US) | 2013-07-09 | — | — | US | disclosed |
| US-20130035348-A1 | ANTIMETASTATIC COMPOUNDS | BRIGHAM YOUNG UNIVERSITY (US) | 2013-02-07 | — | — | US | disclosed |
| US-20130035348-A1 | ANTIMETASTATIC COMPOUNDS | BRIGHAM YOUNG UNIVERSITY (US) | 2013-02-07 | — | — | US | disclosed |
| WO-2011127192-A2 | ANTIMETASTATIC COMPOUNDS | BRIGHAM YOUNG UNIVERSITY (US) | 2011-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225610-A1 | ANTIMETASTATIC COMPOUNDS | MET, HGFAC, HGF | ALDH1A1 855/4885MAPK10 204/4885LMNA 3658/4885 |
| US-20160354375-A1 | CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES SUCH AS TAUOPATHIES | CSNK1G1, CSNK1A1, CSNK1D | ALDH1A1 2638/4885MAPK10 650/4885LMNA 879/4885 |
| US-20130035348-A1 | ANTIMETASTATIC COMPOUNDS | MET, HGFAC, HGF | ALDH1A1 855/4885MAPK10 204/4885LMNA 3658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.