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Sugi Predict / Targets / LYPLA1

LYPLA1

Acyl-protein thioesterase 1 · O75608 · LYPLA1 on Sugi Atlas →

788 patent compounds predicted against LYPLA1, 441 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL20805421 SCHEMBL20805421 0.64 6/20
SCHEMBL12370961 SCHEMBL12370961 0.59 6/20
SCHEMBL12370966 SCHEMBL12370966 0.52 6/20
SCHEMBL3402991 SCHEMBL3402991 0.51 6/20
SCHEMBL10083462 SCHEMBL10083462 0.55 5/20
SCHEMBL10555179 SCHEMBL10555179 0.50 5/20
SCHEMBL21679671 SCHEMBL21679671 0.47 5/20
SCHEMBL12395555 SCHEMBL12395555 0.43 5/20
SCHEMBL4432746 SCHEMBL4432746 0.64 4/20
SCHEMBL7623021 SCHEMBL7623021 0.64 4/20
SCHEMBL15536870 SCHEMBL15536870 0.64 4/20
SCHEMBL15536871 SCHEMBL15536871 0.64 4/20
SCHEMBL15834386 SCHEMBL15834386 0.64 4/20
SCHEMBL16616536 SCHEMBL16616536 0.64 4/20
SCHEMBL16616539 SCHEMBL16616539 0.64 4/20
SCHEMBL16617217 SCHEMBL16617217 0.64 4/20
SCHEMBL16617219 SCHEMBL16617219 0.64 4/20
SCHEMBL17760876 SCHEMBL17760876 0.64 4/20
SCHEMBL17866920 SCHEMBL17866920 0.64 4/20
SCHEMBL19514927 SCHEMBL19514927 0.64 4/20

Clinical trials — most relevant to LYPLA1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Cystagon to Treat Infantile Neuronal Ceroid Lipofuscinosis PHASE4COMPLETED
Acid Lipase Replacement Investigating Safety and Efficacy (ARISE) in Participants With Lysosomal Acid Lipase Deficiency PHASE3COMPLETED
A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) Administered to Patients With Familial Chylomicronemia Syndrome (FCS) PHASE3COMPLETED
Cholic Acid for Hepatic Steatosis in Lipodystrophy PHASE2COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides PHASE1COMPLETED
Biomarker for Wolman Disease (BioWolman) nanWITHDRAWN
Lipa Gene Mutation in PED-LIPIGEN (Pediatric FH Subjects) nanUNKNOWN
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Epidemiology of Atherosclerosis nanCOMPLETED
In Vivo Metabolism of apoB-containing Lipoproteins in ANGPTL3 Deficient Subjects nanUNKNOWN
Physiopathology of Pulmonary Arterial Hypertension: Mechanistic Studies nanUNKNOWN
RCDP Natural History Study nanUNKNOWN
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes nanRECRUITING
A Retrospective Natural History Study of Patients With Lysosomal Acid Lipase Deficiency/Wolman Phenotype nanCOMPLETED
The Classification and Cause of Leukodystrophies of Unknown Cause nanCOMPLETED
Lysosomal Acid Lipase (LAL) Deficiency Registry nanRECRUITING
Familial Partial Lipodystrophy Study nanCOMPLETED
Development of Biomarker for Development of Non-Alcoholic Steatohepatitis (NASH) in Children nanWITHDRAWN
for Adipose Tissue DIabetes VAriants (fATDIVA) nanCOMPLETED
An Observational Study of Patients With Lysosomal Acid Lipase Deficiency/Cholesteryl Ester Storage Disease Phenotype nanCOMPLETED
Serum Betatrophin Levels and Its Influencing Factors in Patients With Hyperthyroidism nanUNKNOWN
Genetic and Environmental Determinants of Triglycerides (GOLDN) nanCOMPLETED
Identification of a New Gene Involved in Hereditary Lipodystrophy nanCOMPLETED
Effect of Saturated Fat on Large Low-density Lipoprotein (LDL) and High-density Lipoprotein (HDL) nanCOMPLETED
Natural History of the Leukodystrophies nanCOMPLETED
Genes Involved in Lipid Disorders nanCOMPLETED
Lipodystrophy Connect Patient Registry nanCOMPLETED
Leptin for Abnormal Lipid Kinetics in HIV Lipodystrophy Syndrome nanCOMPLETED
Combining Gene Variants to Improve Risk Prediction for Metabolic (Dysfunction)- Associated Fatty Liver Disease and Its Progression to Cirrhosis in Indian Individuals With Type 2 Diabetes nanCOMPLETED
Structural Network on Prostate Cancer in the French Greater West Region nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a LYPLA1 binder may also engage these)

ProteinNameSimilarity
Q3MHR0 — 1.000 Q3MHR0 →
O77821 — 0.999 O77821 →
P97823 — 0.997 P97823 →
Q5RBR7 — 0.997 Q5RBR7 →
P70470 — 0.996 P70470 →
Q4I8Q4 — 0.959 Q4I8Q4 →
Q9HFJ5 — 0.954 Q9HFJ5 →
Q0V9A9 — 0.949 Q0V9A9 →
Q84WK4 — 0.946 Q84WK4 →
Q5XGR8 — 0.945 Q5XGR8 →
Q42539 — 0.943 Q42539 →
A0A1F3 — 0.942 A0A1F3 →
Q9XT87 — 0.942 Q9XT87 →
Q42563 — 0.941 Q42563 →
B4G0F3 — 0.941 B4G0F3 →
P00341 — 0.940 P00341 →
Q8GWU0 — 0.940 Q8GWU0 →
P33571 — 0.940 P33571 →
Q6P7K0 — 0.940 Q6P7K0 →
LDHA L-lactate dehydrogenase A chain 0.939 landscape →
PCMT1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase 0.939 landscape →
Q8R1G2 — 0.939 Q8R1G2 →
Q53H82 — 0.939 Q53H82 →
P13221 — 0.939 P13221 →
Q95028 — 0.939 Q95028 →
Q9PT42 — 0.939 Q9PT42 →
P00337 — 0.939 P00337 →
Q9D379 — 0.939 Q9D379 →
P16125 — 0.938 P16125 →
Q4R5H0 — 0.938 Q4R5H0 →