LYPLAL1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL6636334	0.50	1/20
SCHEMBL3525462	0.45	1/20
SCHEMBL3527557	0.42	1/20
SCHEMBL17731564	0.41	1/20
SCHEMBL692531	0.41	1/20
SCHEMBL12204567	0.41	1/20
SCHEMBL3524214	0.41	1/20
SCHEMBL5433847	0.41	1/20
SCHEMBL14457118	0.40	1/20

Clinical trials — most relevant to LYPLAL1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Acid Lipase Replacement Investigating Safety and Efficacy (ARISE) in Participants With Lysosomal Acid Lipase Deficiency	PHASE3	COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides	PHASE1	COMPLETED
Assessment of Coronary Plaque Composition	PHASE1	COMPLETED
Assessment of Coronary Plaque Composition Using Optical Coherence Tomography	PHASE1	COMPLETED
the Role of plin5 in the Development of Nonalcoholic Fatty Liver Disease.	nan	UNKNOWN
Lipa Gene Mutation in PED-LIPIGEN (Pediatric FH Subjects)	nan	UNKNOWN
Autotaxin (ATX) as a Marker for Breast Cancer	nan	UNKNOWN
Physiopathology of Pulmonary Arterial Hypertension: Mechanistic Studies	nan	UNKNOWN
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes	nan	RECRUITING
Genetic Mapping of Atherogenic Lipoprotein Phenotypes	nan	COMPLETED
In Vivo Metabolism of apoB-containing Lipoproteins in ANGPTL3 Deficient Subjects	nan	UNKNOWN
The Efficacy of Pedometer-motivated Physical Activity for the Management of Patients With MASLD.	nan	ENROLLING_BY_INVITATION
Genetical Background of Non-alcoholic Fatty Liver Disease (NAFLD) in Diabetes Mellitus and in Chronic Kidney Disease	nan	UNKNOWN
Lipoprotein-associated Phospholipase A2 in Patients With Type 2 Diabetes	nan	COMPLETED
Multi-Analyte, Genetic, and Thrombogenic Markers of Atherosclerosis	nan	UNKNOWN
Cardiac Biomarkers in Preeclampsia: Prediction of Disease and the Risk of Future Cardiovascular Events in Survivors	nan	UNKNOWN
Correlation of Polymorphisms of Lipoprotein Lipase (LpL) and Apolipoprotein E (Apo E) With Lipid Profile of Children With Acute Lymphoblastic Eukaemia During Therapy With L - Asparaginase.	nan	UNKNOWN
Evaluation of Cascade Screening for Elevated Lipoprotein(a)	nan	ACTIVE_NOT_RECRUITING
Evaluation of Genetic-molecular Causes of Out-of-Hospital Cardiac Arrest: From Patients to Families	nan	RECRUITING
Identification of a New Gene Involved in Hereditary Lipodystrophy	nan	COMPLETED
Genetic Epidemiology of Hypertriglyceridemia	nan	COMPLETED
Natural History of Sphingosine Phosphate Lyase Insufficiency Syndrome (SPLIS)	nan	RECRUITING
Combining Gene Variants to Improve Risk Prediction for Metabolic (Dysfunction)- Associated Fatty Liver Disease and Its Progression to Cirrhosis in Indian Individuals With Type 2 Diabetes	nan	COMPLETED
Assessment of Lipoprotein(a) and Endogenous Fibrinolysis in Atherosclerotic Cardiovascular Disease/Aortic Valve Disease	nan	RECRUITING
for Adipose Tissue DIabetes VAriants (fATDIVA)	nan	COMPLETED
Influence of Pelacarsen on Patients After Myocardial Infarction With High Lp(a) Values (PEMILA)	nan	WITHDRAWN
Identification of Women With Severe Insulin Resistant Syndromes of Genetic Origin Among Patients With Classic Polycystic Ovary Syndrome (PCOS)	nan	NOT_YET_RECRUITING
Genetics of Low Density Lipoprotein Subclasses in Hypercholesterolemia	nan	COMPLETED
A Retrospective Natural History Study of Patients With Lysosomal Acid Lipase Deficiency/Wolman Phenotype	nan	COMPLETED
Lipoprotein (a) and Vascular Regenerative Cell Content	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a LYPLAL1 binder may also engage these)

Protein	Name	Similarity
Q5R8C2	—	1.000	Q5R8C2 →
Q3UFF7	—	0.987	Q3UFF7 →
Q5F477	—	0.947	Q5F477 →
Q5RBU3	—	0.946	Q5RBU3 →
CMBL	Carboxymethylenebutenolidase homolog	0.940	landscape →
Q8R1G2	—	0.940	Q8R1G2 →
Q5FVD6	—	0.940	Q5FVD6 →
Q2RAK2	—	0.938	Q2RAK2 →
Q6PC62	—	0.937	Q6PC62 →
Q7TP52	—	0.937	Q7TP52 →
Q8IX04	—	0.936	Q8IX04 →
Q9H4I8	—	0.936	Q9H4I8 →
Q9H867	—	0.935	Q9H867 →
Q3MHR0	—	0.934	Q3MHR0 →
B8BJ39	—	0.934	B8BJ39 →
Q2QXR8	—	0.934	Q2QXR8 →
B8BM17	—	0.933	B8BM17 →
Q5XH09	—	0.933	Q5XH09 →
BPHL	Serine hydrolase BPHL	0.932	landscape →
Q05B63	—	0.932	Q05B63 →
Q3T0Z7	—	0.931	Q3T0Z7 →
O23653	—	0.931	O23653 →
Q9UJ70	—	0.931	Q9UJ70 →
A0A3L7I2I8	—	0.931	A0A3L7I2I8 →
O35678	—	0.930	O35678 →
PPME1	Protein phosphatase methylesterase 1	0.930	landscape →
P97819	—	0.930	P97819 →
MGLL	Monoglyceride lipase	0.930	landscape →
P97570	—	0.930	P97570 →
Q9CWH5	—	0.930	Q9CWH5 →