Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.31 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.31 |
| ▸ | TRPV2 | Q9Y5S1 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14666732 | 0.77 | HTR2C (0.50) | KDM4EHTTALDH1A1ATMHTR2C | |
| SCHEMBL9679204 | 0.77 | ALDH1A1 (0.41) | KDM4EALDH1A1GAATSHRMEN1 | |
| SCHEMBL12180466 | 0.76 | KDM4E (0.38) | KDM4EHTTALDH1A1F2GAA | |
| SCHEMBL12301085 | 0.74 | KDM4E (0.36) | KDM4EHTTALDH1A1F2GAA | |
| SCHEMBL7466569 | 0.73 | KDM4E (0.60) | KDM4EHTTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL17193802 | 0.73 | KDM4E (0.34) | KDM4EHTTALDH1A1F2GAA | |
| SCHEMBL12233255 | 0.73 | KDM4E (0.35) | KDM4EHTTALDH1A1F2GAA | |
| SCHEMBL19954246 | 0.71 | AKT1 (0.35) | KDM4EHTTALDH1A1F2GAA | |
| SCHEMBL12301083 | 0.70 | KDM4E (0.46) | KDM4EHTTALDH1A1SMN1; SMN2ATM | |
| SCHEMBL6130742 | 0.70 | AKT1 (0.42) | KDM4EALDH1A1GAAALOX12CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017635-B2 | Phenylalkyl substituted heteroaryl derivatives | FMC CORPORATION (US) | 2011-09-13 | — | — | US | disclosed |
| US-8017635-B2 | Phenylalkyl substituted heteroaryl derivatives | FMC CORPORATION (US) | 2011-09-13 | — | — | US | disclosed |
| US-20100152045-A1 | Phenylalkyl Substituted Heteroaryl Derivatives | FMC CORPORATION | 2010-06-17 | — | — | US | disclosed |
| US-20100152045-A1 | Phenylalkyl Substituted Heteroaryl Derivatives | FMC CORPORATION | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152045-A1 | Phenylalkyl Substituted Heteroaryl Derivatives | DDT, CRYAA, CYP19A1 | KDM4E 1083/4885HTT 2985/4885ALDH1A1 830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.