Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ATM | Q13315 | 3/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 6/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12301085 | 0.77 | KDM4E (0.36) | KDM4EATMRAD52MAPTHTT | |
| SCHEMBL12233255 | 0.75 | KDM4E (0.35) | KDM4EATMRAD52HTTLMNA | |
| SCHEMBL12180466 | 0.74 | KDM4E (0.38) | KDM4EATMRAD52MAPTHTT | |
| SCHEMBL18469509 | 0.72 | KDM4E (0.33) | KDM4EATMRAD52HTTALDH1A1 | |
| SCHEMBL14449367 | 0.72 | KDM4E (0.33) | KDM4EATMRAD52MAPTHTT | |
| SCHEMBL17193802 | 0.71 | KDM4E (0.34) | KDM4EATMRAD52HTTLMNA | |
| SCHEMBL12301086 | 0.70 | KDM4E (0.33) | KDM4EATMRAD52HTTKMT2A | |
| SCHEMBL19954246 | 0.67 | AKT1 (0.35) | KDM4EATMHTTLMNAALDH1A1 | |
| SCHEMBL17208907 | 0.67 | ADRA2A (0.35) | KDM4EATMRAD52HTTALDH1A1 | |
| SCHEMBL14449822 | 0.67 | HTR1A (0.35) | KDM4EATMRAD52HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017635-B2 | Phenylalkyl substituted heteroaryl derivatives | FMC CORPORATION (US) | 2011-09-13 | — | — | US | disclosed |
| US-8017635-B2 | Phenylalkyl substituted heteroaryl derivatives | FMC CORPORATION (US) | 2011-09-13 | — | — | US | disclosed |
| US-20100152045-A1 | Phenylalkyl Substituted Heteroaryl Derivatives | FMC CORPORATION | 2010-06-17 | — | — | US | disclosed |
| US-20100152045-A1 | Phenylalkyl Substituted Heteroaryl Derivatives | FMC CORPORATION | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152045-A1 | Phenylalkyl Substituted Heteroaryl Derivatives | DDT, CRYAA, CYP19A1 | KDM4E 1083/4885ATM 3649/4885RAD52 2693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.