Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.57 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.57 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.54 |
| ▸ | ALB | P02768 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 4/20 | 0.40 |
| ▸ | CA2 | P00918 | 4/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12311704 | 0.89 | SIRT5 (0.52) | SIRT6SIRT1SIRT5ALBSMN1; SMN2 | |
| SCHEMBL14601040 | 0.86 | SIRT5 (0.65) | SIRT6SIRT1SIRT5ALBSMN1; SMN2 | |
| SCHEMBL12892923 | 0.85 | SIRT5 (0.55) | SIRT6SIRT1SIRT5ALBSMN1; SMN2 | |
| SCHEMBL13635157 | 0.84 | SIRT5 (0.65) | SIRT6SIRT1SIRT5ALBSMN1; SMN2 | |
| SCHEMBL12311708 | 0.84 | SIRT5 (0.65) | SIRT6SIRT1SIRT5ALBSMN1; SMN2 | |
| SCHEMBL22020896 | 0.83 | SIRT6 (0.54) | SIRT6SIRT1SIRT5ALBSMN1; SMN2 | |
| SCHEMBL929209 | 0.83 | KDM4E (0.52) | SIRT6SIRT1SIRT5SMN1; SMN2KDM4E | |
| SCHEMBL14682789 | 0.81 | SIRT6 (0.62) | SIRT6SIRT1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL930076 | 0.81 | KDM4E (0.53) | SIRT6SIRT1SIRT5SMN1; SMN2KDM4E | |
| SCHEMBL13446714 | 0.80 | SIRT5 (0.54) | SIRT6SIRT1SIRT5ALBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9133260-B2 | GIP analog and hybrid polypeptides with selectable properties | AMYLIN PHARMACEUTICALS, LLC (US) | 2015-09-15 | — | — | US | disclosed |
| US-8895498-B2 | GIP and exendin hybrid polypeptides | ASTRAZENECA PHARMACEUTICALS, LP (US) | 2014-11-25 | — | — | US | disclosed |
| US-20130281374-A1 | DPP-IV RESISTANT GIP HYBRID POLYPEPTIDES WITH SELECTABLE PROPERTIES | ASTRAZENECA PHARMACEUTICALS LP (US) | 2013-10-24 | — | — | US | disclosed |
| US-20130196913-A1 | GIP ANALOG AND HYBRID POLYPEPTIDES WITH SELECTABLE PROPERTIES | ASTRAZENECA PHARMACEUTICALS LP (US) | 2013-08-01 | — | — | US | disclosed |
| US-8497240-B2 | DPP-IV resistant GIP hybrid polypeptides with selectable properties | AMYLIN PHARMACEUTICALS, LLC (US) | 2013-07-30 | — | — | US | disclosed |
| US-20130137631-A1 | GIP ANALOG AND HYBRID POLYPEPTIDES WITH SELECTABLE PROPERTIES | AMYLIN PHARMACEUTICALS, LLC (US) | 2013-05-30 | — | — | US | disclosed |
| US-8404637-B2 | GIP analog and hybrid polypeptides with selectable properties | AMYLIN PHARMACEUTICALS, LLC (US) | 2013-03-26 | — | — | US | disclosed |
| US-8263545-B2 | GIP analog and hybrid polypeptides with selectable properties | AMYLIN PHARMACEUTICALS, INC. (US) | 2012-09-11 | — | — | US | disclosed |
| US-20110136737-A1 | DPP-IV Resistant GIP Hybrid Polypeptides with Selectable Properties | AMYLIN PHARMACEUTICALS, INC. (US) | 2011-06-09 | — | — | US | disclosed |
| US-20090036364-A1 | GIP ANALOG AND HYBRID POLYPEPTIDES WITH SELECTABLE PROPERTIES | AMYLIN PHARMACEUTICALS, INC. (US) | 2009-02-05 | — | — | US | disclosed |
| US-20080312157-A1 | GIP ANALOG AND HYBRID POLYPEPTIDES WITH SELECTABLE PROPERTIES | AMYLIN PHARMACEUTICALS, INC. (US) | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312157-A1 | GIP ANALOG AND HYBRID POLYPEPTIDES WITH SELECTABLE PROPERTIES | GIPR, GLP1R, VIP | SIRT6 4374/4885SIRT1 3123/4885SIRT5 4043/4885 |
| US-20130196913-A1 | GIP ANALOG AND HYBRID POLYPEPTIDES WITH SELECTABLE PROPERTIES | GIPR, GLP1R, VIP | SIRT6 4374/4885SIRT1 3123/4885SIRT5 4043/4885 |
| US-20110136737-A1 | DPP-IV Resistant GIP Hybrid Polypeptides with Selectable Properties | GIPR, DPP4, GLP1R | SIRT6 4268/4885SIRT1 3484/4885SIRT5 4286/4885 |
| US-20090036364-A1 | GIP ANALOG AND HYBRID POLYPEPTIDES WITH SELECTABLE PROPERTIES | GIPR, GLP1R, VIP | SIRT6 4374/4885SIRT1 3123/4885SIRT5 4043/4885 |
| US-20130281374-A1 | DPP-IV RESISTANT GIP HYBRID POLYPEPTIDES WITH SELECTABLE PROPERTIES | GIPR, DPP4, GLP1R | SIRT6 4268/4885SIRT1 3484/4885SIRT5 4286/4885 |
| US-20130137631-A1 | GIP ANALOG AND HYBRID POLYPEPTIDES WITH SELECTABLE PROPERTIES | GIPR, GLP1R, VIP | SIRT6 4374/4885SIRT1 3123/4885SIRT5 4043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.