Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CHAT | P28329 | 4/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL50727 | 0.82 | BACE1 (0.43) | TSHRHSD17B10RXRAALDH1A1CYP2A6 | |
| SCHEMBL29374287 | 0.80 | RXRA (0.47) | TSHRHSD17B10RXRAALDH1A1CYP2A6 | |
| SCHEMBL2662479 | 0.80 | RXRA (0.47) | TSHRHSD17B10RXRAALDH1A1CYP2A6 | |
| SCHEMBL7888602 | 0.80 | RXRA (0.47) | TSHRHSD17B10RXRAALDH1A1CYP2A6 | |
| SCHEMBL1033619 | 0.79 | ALDH1A1 (0.46) | TSHRHSD17B10ALDH1A1TDP1CYP1A2 | |
| SCHEMBL2494362 | 0.79 | TSHR (0.50) | TSHRHSD17B10RXRAALDH1A1CYP2A6 | |
| SCHEMBL816177 | 0.79 | TSHR (0.50) | TSHRHSD17B10RXRAALDH1A1CYP2A6 | |
| SCHEMBL10706694 | 0.79 | CHAT (0.62) | TSHRHSD17B10RXRAALDH1A1CYP2A6 | |
| SCHEMBL10706687 | 0.79 | CHAT (0.62) | TSHRHSD17B10RXRAALDH1A1CYP2A6 | |
| SCHEMBL10706700 | 0.79 | CHAT (0.62) | TSHRHSD17B10RXRAALDH1A1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4322 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116143770-A | Quinoline derivative and preparation method and application thereof | 广东工业大学 | 2023-05-23 | — | — | CN | claimed |
| CN-116003460-A | Method for synthesizing optical active organosilicon compound by asymmetric conjugate addition | 河南师范大学 | 2023-04-25 | — | — | CN | claimed |
| EP-2879675-B1 | COMPOUNDS AND METHODS FOR TARGETING HSP90 | UNIV DUKE (US) | 2019-11-13 | — | — | EP | claimed |
| CN-106103440-B | Compound, luminescent material and organic electroluminescence device with the tetrazine and phenanthrene ring structure | 保土谷化学工业株式会社 | 2019-03-26 | — | — | CN | claimed |
| CN-108299285-A | The synthetic method of trifluoromethyl Dihydropyridone compound | 河南师范大学 | 2018-07-20 | — | — | CN | claimed |
| EP-2528901-B9 | PYRAZOLE COMPOUNDS AS CRTH2 ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2017-01-25 | — | — | EP | claimed |
| CN-105408325-A | Cyanotriazole compounds | OTSUKA PHARMA CO LTD | 2016-03-16 | — | — | CN | claimed |
| EP-2528901-B1 | PYRAZOLE COMPOUNDS AS CRTH2 ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2015-05-27 | — | — | EP | claimed |
| US-8791272-B2 | Pyrazole compounds as CRTH2 antagonists | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-07-29 | — | — | US | claimed |
| CN-103413683-A | Preparation of electron beam irradiation modified flexible dye-sensitized nanocrystalline solar cell | INST MODERN PHYSICS CAS | 2013-11-27 | — | — | CN | claimed |
| WO-2001062709-A2 | USE OF 2-PHENYLENE DIAMINE DERIVATIVES FOR THE TREATMENT OF INFECTIONS | JOMAA PHARMAKA GMBH (DE) | 2001-08-30 | — | — | WO | claimed |
| EP-1068176-A1 | CYSTEINE AMIDES AS FARNESYL TRANSFERASE INHIBITORS | Jomaa, Hassan (DE) | 2001-01-17 | — | — | EP | claimed |
| WO-2000027803-A1 | CYSTEINE AMIDES AS FARNESYL TRANSFERASE INHIBITORS | JOMAA, HASSAN (DE) | 2000-05-18 | — | — | WO | claimed |
| US-5932601-A | USEFUL FOR LOWERING BLOOD SUGAR AND LIPID IN BLOOD | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-08-03 | — | — | US | claimed |
| EP-0463488-B1 | O-Benzyl oxime ethers and fungicides containing them | BASF AG (DE) | 1997-12-10 | — | — | EP | claimed |
| US-5587373-A | ELASTASE INHIBITORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1996-12-24 | — | — | US | claimed |
| EP-0445781-B1 | 3-Arylcarbonyl-1-aminoalkyl-1H-indole containing antiglaucoma compositions | STERLING WINTHROP INC (US) | 1996-01-31 | — | — | EP | claimed |
| EP-0445781-A1 | 3-Arylcarbonyl-1-aminoalkyl-1H-indole containing antiglaucoma compositions | STERLING WINTHROP INC. (US) | 1991-09-11 | — | — | EP | claimed |
| US-5013837-A | Treatment of glaucoma | STERLING DRUG INC. (US) | 1991-05-07 | — | — | US | claimed |
| US-4973587-A | 3-arylcarbonyl-1-aminoalkyl-1H-indole-containing antiglaucoma method | STERLING DRUG INC. (US) | 1990-11-27 | — | — | US | claimed |