Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.34 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.34 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.34 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.33 |
| ▸ | GSR | P00390 | 1/20 | 0.33 |
| ▸ | TLR2 | O60603 | 2/20 | 0.33 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.33 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.33 |
| ▸ | NMT2 | O60551 | 1/20 | 0.32 |
| ▸ | NMT1 | P30419 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12812737 | 0.82 | SIRT6 (0.39) | SIRT6SIRT1FOLH1DPP8DPP9 | |
| SCHEMBL13233703 | 0.76 | SIRT6 (0.42) | SIRT6SIRT1FOLH1GNAI3GNAO1 | |
| SCHEMBL19605496 | 0.76 | SIRT6 (0.42) | SIRT6SIRT1FOLH1GNAI3GNAO1 | |
| SCHEMBL19386702 | 0.74 | SIRT6 (0.38) | SIRT6SIRT1FOLH1DPP8DPP9 | |
| SCHEMBL16383761 | 0.73 | SIRT6 (0.45) | SIRT6SIRT1FOLH1DPP8DPP9 | |
| SCHEMBL21103612 | 0.73 | GSR (0.53) | DPP8DPP9DPP7GNAI3GNAO1 | |
| SCHEMBL12833333 | 0.73 | GSR (0.53) | DPP8DPP9DPP7GNAI3GNAO1 | |
| SCHEMBL14342256 | 0.73 | SIRT6 (0.45) | SIRT6SIRT1FOLH1DPP8DPP9 | |
| SCHEMBL18868852 | 0.73 | GSR (0.53) | DPP8DPP9DPP7GNAI3GNAO1 | |
| SCHEMBL18821567 | 0.72 | SIRT6 (0.39) | SIRT6SIRT1FOLH1DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119887-A1 | RNA INTERFERENCE IN DERMAL AND FIBROTIC INDICATIONS | RXI PHARMACEUTICALS CORPORATION (US) | 2011-09-29 | — | — | WO | disclosed |