Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 1/20 | 0.57 |
| ▸ | TOP2A | P11388 | 1/20 | 0.57 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.47 |
| ▸ | PLG | P00747 | 4/20 | 0.45 |
| ▸ | PLAU | P00749 | 4/20 | 0.45 |
| ▸ | ACHE | P22303 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16586563 | 0.90 | PLG (0.50) | TOP1TOP2ACYP1A1CYP1A2CYP1B1 | |
| SCHEMBL1232791 | 0.87 | PLG (0.51) | TOP1TOP2ACHEK2PLGPLAU | |
| SCHEMBL16586719 | 0.86 | PLG (0.52) | TOP1TOP2ACHEK2PLGPLAU | |
| SCHEMBL23424115 | 0.84 | CHEK2 (0.64) | CHEK2PLGPLAUACHEKDM4E | |
| SCHEMBL20982796 | 0.82 | MEN1 (0.57) | KDM4ENPC1USP2ALDH1A1TP53 | |
| SCHEMBL10061954 | 0.79 | CYP1A1 (0.69) | TOP1TOP2ACYP1A1CYP1A2CYP1B1 | |
| SCHEMBL2562072 | 0.76 | NPBWR1 (0.59) | TOP1TOP2ACHEK2KDM4ENPC1 | |
| SCHEMBL4396538 | 0.76 | NPC1 (0.60) | CYP1A2CHEK2PLAUKDM4ENPC1 | |
| SCHEMBL10737800 | 0.75 | CYP1A1 (0.57) | TOP1TOP2ACYP1A1CYP1A2CYP1B1 | |
| SCHEMBL12888578 | 0.75 | CHEK2 (0.55) | TOP1TOP2APARP1CHEK2PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920014-B2 | Selective inhibition of bacterial topoisomerase I | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2018-03-20 | — | — | US | disclosed |
| US-9492554-B2 | Methods and compositions related to viral inhibition | CLEMSON UNIVERSITY (US) | 2016-11-15 | — | — | US | disclosed |
| US-9492554-B2 | Methods and compositions related to viral inhibition | CLEMSON UNIVERSITY (US) | 2016-11-15 | — | — | US | disclosed |
| US-20160263231-A1 | Methods and Compositions Related to Viral Inhibition | CLEMSON UNIVERSITY | 2016-09-15 | — | — | US | disclosed |
| US-20160263231-A1 | Methods and Compositions Related to Viral Inhibition | CLEMSON UNIVERSITY | 2016-09-15 | — | — | US | disclosed |
| US-20160229810-A1 | Selective Inhibition of Bacterial Topoisomerase I | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2016-08-11 | — | — | US | disclosed |
| US-9072761-B2 | Methods and compositions related to viral inhibition | CLEMSON UNIVERSITY RESEARCH FOUNDATION (CURF) (US) | 2015-07-07 | — | — | US | disclosed |
| US-9072761-B2 | Methods and compositions related to viral inhibition | CLEMSON UNIVERSITY RESEARCH FOUNDATION (CURF) (US) | 2015-07-07 | — | — | US | disclosed |
| WO-2015042438-A1 | SELECTIVE INHIBITION OF BACTERIAL TOPOISOMERASE I | THE FLORIDA INTERNATIONAL BOARD OF TRUSTEES MODESTO A. MAIDIQUE CAMPUS (US) | 2015-03-26 | — | — | WO | disclosed |
| US-20110046982-A1 | METHODS AND COMPOSITIONS RELATED TO VIRAL INHIBITION | CLEMSON UNIVERSITY RESEARCH FOUNDATION (CURF) (US) | 2011-02-24 | — | — | US | disclosed |
| US-20110046982-A1 | METHODS AND COMPOSITIONS RELATED TO VIRAL INHIBITION | CLEMSON UNIVERSITY RESEARCH FOUNDATION (CURF) (US) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229810-A1 | Selective Inhibition of Bacterial Topoisomerase I | TOP1, TOP2B, TOP2A | TOP1 1/4885TOP2A 3/4885CYP1A1 1995/4885 |
| US-20160263231-A1 | Methods and Compositions Related to Viral Inhibition | EIF2AK2, NSUN2, NSUN3 | TOP1 612/4885TOP2A 716/4885CYP1A1 4203/4885 |
| US-20110046982-A1 | METHODS AND COMPOSITIONS RELATED TO VIRAL INHIBITION | EIF2AK2, NSUN2, NSUN3 | TOP1 612/4885TOP2A 716/4885CYP1A1 4203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.