Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 4/20 | 0.50 |
| ▸ | PLAU | P00749 | 4/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.48 |
| ▸ | TOP1 | P11387 | 1/20 | 0.48 |
| ▸ | TOP2A | P11388 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.47 |
| ▸ | ACHE | P22303 | 5/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1232791 | 0.91 | PLG (0.51) | PLGPLAUCHEK2TOP1TOP2A | |
| SCHEMBL1233401 | 0.90 | TOP1 (0.57) | PLGPLAUCHEK2TOP1TOP2A | |
| SCHEMBL16586719 | 0.90 | PLG (0.52) | PLGPLAUCHEK2TOP1TOP2A | |
| SCHEMBL23424115 | 0.80 | CHEK2 (0.64) | PLGPLAUCHEK2HDAC6ACHE | |
| SCHEMBL16586792 | 0.78 | CHEK2 (0.57) | PLGPLAUCHEK2HDAC6ACHE | |
| SCHEMBL16585081 | 0.78 | ALDH1A1 (0.51) | HDAC3HDAC2HDAC8 | |
| SCHEMBL20982796 | 0.78 | MEN1 (0.57) | HDAC6 | |
| SCHEMBL16586786 | 0.77 | TOP1 (0.83) | TOP1TOP2AACHE | |
| SCHEMBL20982466 | 0.74 | CHEK2 (0.65) | PLGPLAUCHEK2HDAC6ACHE | |
| SCHEMBL23424051 | 0.74 | CHEK2 (0.48) | PLGPLAUCHEK2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920014-B2 | Selective inhibition of bacterial topoisomerase I | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2018-03-20 | — | — | US | disclosed |
| US-20160229810-A1 | Selective Inhibition of Bacterial Topoisomerase I | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2016-08-11 | — | — | US | disclosed |
| WO-2015042438-A1 | SELECTIVE INHIBITION OF BACTERIAL TOPOISOMERASE I | THE FLORIDA INTERNATIONAL BOARD OF TRUSTEES MODESTO A. MAIDIQUE CAMPUS (US) | 2015-03-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229810-A1 | Selective Inhibition of Bacterial Topoisomerase I | TOP1, TOP2B, TOP2A | PLG 4101/4885PLAU 4142/4885CHEK2 259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.