Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 3/20 | 0.59 |
| ▸ | RORC | P51449 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | GPR27 | Q9NS67 | 2/20 | 0.52 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KLK7 | P49862 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12334376 | 0.89 | RORC (0.65) | RORCNPC1RAB9ASMN1; SMN2GPR27 | |
| SCHEMBL12334252 | 0.86 | SNCA (0.56) | SNCANPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL12334654 | 0.86 | RORC (0.70) | RORCNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL12334377 | 0.86 | RORC (0.58) | SNCARORCMAPTSMN1; SMN2GPR27 | |
| SCHEMBL12334586 | 0.83 | RORC (0.72) | RORCNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL5314331 | 0.81 | RORC (0.79) | SNCARORCNPC1RAB9AMAPT | |
| SCHEMBL27964618 | 0.78 | SNCA (0.67) | SNCANPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL677811 | 0.78 | SNCA (0.67) | SNCANPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL31078087 | 0.78 | RORC (0.65) | RORCNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL6544935 | 0.77 | GPR27 (0.72) | SNCANPC1RAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011115892-A1 | MODULATORS OF THE RETINOIC ACID RECEPTOR-RELATED ORPHAN RECEPTORS | GRIFFIN PATRICK R (US) | 2011-09-22 | — | — | WO | disclosed |