Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29391873 | 0.86 | ALDH1A1 (0.37) | CARM1PRMT6HTTALDH1A1PKM | |
| SCHEMBL11927511 | 0.84 | ALDH1A1 (0.36) | CARM1PRMT6ALDH1A1PKMKMT2A | |
| SCHEMBL10316243 | 0.82 | PKM (0.49) | CARM1PRMT6HTTALDH1A1PKM | |
| SCHEMBL17207600 | 0.82 | CYP11B2 (0.41) | HTTALDH1A1KMT2A | |
| SCHEMBL13798599 | 0.81 | HSD17B10 (0.41) | HSD17B10PDE4BITGB3ITGA2BHTT | |
| SCHEMBL8337260 | 0.81 | SMN1; SMN2 (0.42) | ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL669964 | 0.81 | LTA4H (0.45) | HSD17B10CARM1PRMT6ALDH1A1PKM | |
| SCHEMBL12404059 | 0.79 | KMT2A (0.42) | HSD17B10PDE4BITGB3ITGA2BHTT | |
| SCHEMBL14887154 | 0.79 | ALDH1A1 (0.46) | CARM1PRMT6ALDH1A1PKMKMT2A | |
| SCHEMBL13282353 | 0.79 | KMT2A (0.36) | CARM1PRMT6ALDH1A1PKMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170260174-A1 | Benzene, Pyridine, and Pyridazine Derivatives | ESANEX INC (US) | 2017-09-14 | — | — | US | disclosed |
| EP-2380879-B1 | Tetrahydroindolone and tetrahydroindazolone derivatives | ESANEX INC (US) | 2017-07-12 | — | — | EP | disclosed |
| US-9656956-B2 | Benzene, pyridine, and pyridazine derivatives | ESANEX, INC. (US) | 2017-05-23 | — | — | US | disclosed |
| CN-103582638-B | Heteroaryl pyrimidine derivative, preparation method and application thereof | JIANGSU HANSOH PHARMACEUTICAL Co.,Ltd. (CN) | 2016-02-10 | — | — | CN | disclosed |
| US-20140343037-A1 | BENZENE, PYRIDINE, AND PYRIDAZINE DERIVATIVES | SERENEX, INC. | 2014-11-20 | — | — | US | disclosed |
| US-20130137686-A1 | BENZENE, PYRIDINE, AND PYRIDAZINE DERIVATIVES | SERENEX, INC. | 2013-05-30 | — | — | US | disclosed |
| CN-102911172-A | Heteroaryl pyrimidine derivatives and preparation method and application thereof | SHANGHAI HENGRUI MEDICINE CO LTD | 2013-02-06 | — | — | CN | disclosed |
| US-8309548-B2 | Benzene, pyridine, and pyridazine derivatives | SERENEX, INC. (US) | 2012-11-13 | — | — | US | disclosed |
| WO-2011113578-A1 | NEW OXADIAZOLE DERIVATIVES | ALMIRALL, S.A. (ES) | 2011-09-22 | — | — | WO | disclosed |
| US-20110183977-A1 | BENZENE, PYRIDINE, AND PYRIDAZINE DERIVATIVES | SERENEX, INC. (US) | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137686-A1 | BENZENE, PYRIDINE, AND PYRIDAZINE DERIVATIVES | CDK4, P2RX4, MKI67 | HSD17B10 3780/4885CARM1 3353/4885PRMT6 2269/4885 |
| US-20170260174-A1 | Benzene, Pyridine, and Pyridazine Derivatives | CDK4, P2RX4, MKI67 | HSD17B10 3780/4885CARM1 3353/4885PRMT6 2269/4885 |
| US-20140343037-A1 | BENZENE, PYRIDINE, AND PYRIDAZINE DERIVATIVES | CDK4, P2RX4, MKI67 | HSD17B10 3780/4885CARM1 3353/4885PRMT6 2269/4885 |
| US-20110183977-A1 | BENZENE, PYRIDINE, AND PYRIDAZINE DERIVATIVES | CDK4, P2RX4, MKI67 | HSD17B10 3780/4885CARM1 3353/4885PRMT6 2269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.