Sugi Predict

Sugi Predict / Compounds / SCHEMBL1233712

SCHEMBL1233712

SCHEMBL1233712

Nc1nc(C(F)(F)F)nc2nc[nH]c12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDPK1 O15530 1/20 0.59
▸ GDA Q9Y2T3 1/20 0.59
▸ CDK2 P24941 2/20 0.47
▸ PI4KA P42356 2/20 0.47
▸ PI4K2B Q8TCG2 2/20 0.47
▸ PI4K2A Q9BTU6 2/20 0.47
▸ PI4KB Q9UBF8 2/20 0.47
▸ LMNA P02545 1/20 0.47
▸ DRD3 P35462 1/20 0.47
▸ XDH P47989 1/20 0.47
▸ LRRK2 Q5S007 1/20 0.47
▸ DPP4 P27487 1/20 0.43
▸ PNP P00491 1/20 0.42
▸ POLA1 P09884 2/20 0.40
▸ BRAF P15056 1/20 0.40
▸ MAP3K5 Q99683 1/20 0.40
▸ EIF2AK2 P19525 1/20 0.38
▸ KDR P35968 1/20 0.37
▸ AURKB Q96GD4 1/20 0.37
▸ CDK1 P06493 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Formic Acid SCHEMBL5459686 0.91 PDPK1 (0.50) PDPK1GDACDK2PI4KAPI4K2B
SCHEMBL4534389 0.79 CDK2 (0.40) PDPK1GDACDK2XDHDPP4
SCHEMBL3137199 0.79 DPP4 (0.56) PDPK1GDACDK2XDHDPP4
SCHEMBL3136203 0.79 CDK2 (0.40) PDPK1GDACDK2XDHDPP4
SCHEMBL887132 0.76 PDPK1 (0.51) PDPK1GDACDK2PI4KAPI4K2B
SCHEMBL28164496 0.76 PDPK1 (0.51) PDPK1GDACDK2PI4KAPI4K2B
SCHEMBL29375265 0.76 PDPK1 (0.66) PDPK1GDACDK2PI4KAPI4K2B
SCHEMBL8851 0.76 PDPK1 (0.66) PDPK1GDACDK2PI4KAPI4K2B
2,6-Diaminopurine SCHEMBL24053 0.75 PDPK1 (1.00) PDPK1GDACDK2PI4KAPI4K2B
SCHEMBL3137133 0.75 XDH (0.59) CDK2XDHBRAFEIF2AK2CDK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108395432-A A kind of preparation method of 2- trifluoromethyls-adenine 吴江信凯医药科技有限公司 2018-08-14 — — CN claimed
US-20170175129-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS INC (US) 2017-06-22 — — US claimed
US-20170136131-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF Modema Therapeutics, Inc. (US) 2017-05-18 — — US claimed
EP-3157573-A2 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF Moderna Therapeutics, Inc. (US) 2017-04-26 — — EP claimed
EP-3157572-A2 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF Moderna Therapeutics, Inc. (US) 2017-04-26 — — EP claimed
CN-106170553-A Modified nucleic acid molecules and uses thereof 现代治疗公司 2016-11-30 — — CN claimed
US-20160304552-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. 2016-10-20 — — US claimed
EP-3080289-A2 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF Moderna Therapeutics, Inc. (US) 2016-10-19 — — EP claimed
WO-2015196128-A2 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. (US) 2015-12-23 — — WO claimed
WO-2015196130-A2 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. (US) 2015-12-23 — — WO claimed
US-20150307542-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNATX, INC. 2015-10-29 — — US claimed
EP-2931319-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF Moderna Therapeutics, Inc. (US) 2015-10-21 — — EP claimed
WO-2015089511-A2 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. (US) 2015-06-18 — — WO claimed
WO-2014093924-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. (US) 2014-06-19 — — WO claimed
US-20240165267-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF ARES CAPITAL CORPORATION, AS AGENT 2024-05-23 — — US disclosed
US-20190255194-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF MODERNATX INC (US) 2019-08-22 — — US disclosed
EP-2931319-B1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNATX INC (US) 2019-08-21 — — EP disclosed
WO-2008107125-A1 NEW 3-([1,2,4]TRIAZOLO[4,3-A]PYRIDIN-7-YL)BENZAMIDE DERIVATIVES ALMIRALL, S.A. (ES) 2008-09-12 — — WO disclosed
CN-1688580-A 2-Trifluoromethyl-6-aminopurine derivatives as phosphodiesterase 4 inhibitors MEMORY PHARM CORP (US) 2005-10-26 — — CN disclosed
CN-1688580-A 2-Trifluoromethyl-6-aminopurine derivatives as phosphodiesterase 4 inhibitors MEMORY PHARM CORP (US) 2005-10-26 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160304552-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 PDPK1 3533/4885GDA 36/4885CDK2 3750/4885
US-20190255194-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, RNGTT, NSUN3 PDPK1 3868/4885GDA 83/4885CDK2 4020/4885
US-20240165267-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 PDPK1 3533/4885GDA 36/4885CDK2 3750/4885
US-20170175129-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, RNGTT, NSUN3 PDPK1 3868/4885GDA 83/4885CDK2 4020/4885
US-20170136131-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, RNGTT, NSUN3 PDPK1 3868/4885GDA 83/4885CDK2 4020/4885
US-20150307542-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 PDPK1 3533/4885GDA 36/4885CDK2 3750/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.