Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12337178 | 0.82 | OPRM1 (0.38) | — | |
| SCHEMBL18473622 | 0.77 | HCRTR1 (0.40) | HCRTR1ALDH1A1 | |
| SCHEMBL46027 | 0.72 | — | — | |
| SCHEMBL13973195 | 0.71 | HCRTR1 (0.33) | HCRTR1ALDH1A1 | |
| SCHEMBL14292473 | 0.70 | OPRM1 (0.38) | — | |
| SCHEMBL18994720 | 0.69 | OPRD1 (0.41) | ALDH1A1 | |
| SCHEMBL14012718 | 0.69 | OPRM1 (0.33) | — | |
| SCHEMBL19413918 | 0.68 | OPRM1 (0.44) | ALDH1A1 | |
| SCHEMBL10072374 | 0.67 | HCRTR1 (0.42) | HCRTR1 | |
| SCHEMBL13659846 | 0.67 | HCRTR1 (0.40) | HCRTR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8263807-B2 | Quaternary opioid carboxamides | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2012-09-11 | — | — | US | disclosed |
| US-20090197905-A1 | QUATERNARY OPIOID CARBOXAMIDES | RENSSELAER POLYTECHNIC INSTITUTE (US) | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197905-A1 | QUATERNARY OPIOID CARBOXAMIDES | OPRK1, OPRM1, OPRD1 | HCRTR1 14/4885DRD2 342/4885HTR1D 423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.