Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | LIPE | Q05469 | 6/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12244 | 0.87 | LIPE (0.34) | LIPE | |
| SCHEMBL5071 | 0.86 | LIPE (0.43) | LIPE | |
| SCHEMBL1589420 | 0.86 | LIPE (0.43) | LIPE | |
| SCHEMBL12117 | 0.84 | LIPE (0.33) | POLBLIPEMEN1KMT2A | |
| SCHEMBL12337 | 0.80 | MEN1 (0.35) | POLBLIPEMEN1KMT2ACYP1A2 | |
| SCHEMBL12193 | 0.79 | MCOLN3 (0.40) | LIPEMEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL12024 | 0.76 | LIPE (0.35) | LIPE | |
| SCHEMBL12343 | 0.75 | — | — | |
| SCHEMBL11972 | 0.71 | LIPE (0.52) | LIPE | |
| SCHEMBL11971 | 0.71 | LIPE (0.52) | LIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011045292-A1 | SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS HSL INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-04-21 | — | — | WO | disclosed |