SCHEMBL12348441

SCHEMBL12348441

COc1c(Cl)c(N)c(Cl)c(OC)c1Cl

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.31
NPC1 O15118 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10944854 0.89 CA1 (0.32)
SCHEMBL10947434 0.88 KDM4E (0.32) GAANPC1
SCHEMBL31277708 0.84 KDM4E (0.35) GAA
SCHEMBL20745709 0.78 ALDH1A1 (0.35) GAA
SCHEMBL13880635 0.77 KDM4E (0.35) GAA
SCHEMBL10945676 0.74 CA1 (0.33) GAANPC1
SCHEMBL10694680 0.74 IMPDH2 (0.33)
SCHEMBL301807 0.74 CA1 (0.35) GAA
SCHEMBL21170586 0.69 IMPDH2 (0.31)
SCHEMBL12325394 0.69 MGAM (0.34) GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011093672-A2 BICYCLIC HETEROARYL DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE HANMI PHARM. CO., LTD. (KR) 2011-08-04 WO disclosed