Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14856418 | 1.00 | HTR6 (0.36) | HTR6BIRC2CYP2C9TSHRCYP2C19 | |
| Hydrochloric Acid SCHEMBL2237196 | 0.98 | HTR6 (0.35) | HTR6BIRC2CYP2C9TSHRCYP2C19 | |
| SCHEMBL6582291 | 0.94 | HTR6 (0.39) | HTR6BIRC2DPP4MEN1KMT2A | |
| SCHEMBL6582294 | 0.94 | HTR6 (0.39) | HTR6BIRC2DPP4MEN1KMT2A | |
| SCHEMBL23139621 | 0.91 | BIRC2 (0.34) | HTR6BIRC2KMT2A | |
| SCHEMBL25698895 | 0.91 | BIRC2 (0.34) | HTR6BIRC2KMT2A | |
| Hydrochloric Acid SCHEMBL25337896 | 0.89 | HPGD (0.34) | BIRC2KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL25337894 | 0.89 | HPGD (0.34) | BIRC2KMT2AALDH1A1 | |
| SCHEMBL17484304 | 0.85 | HPGD (0.33) | HTR6BIRC2KMT2A | |
| SCHEMBL15933081 | 0.83 | ALDH1A1 (0.42) | BIRC2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150164888-A1 | CYCLOPROPYL AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2015-06-18 | — | — | US | disclosed |
| US-20150164889-A1 | CYCLOPROPYL AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2015-06-18 | — | — | US | disclosed |
| US-20150164888-A1 | CYCLOPROPYL AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2015-06-18 | — | — | US | disclosed |
| US-20150164889-A1 | CYCLOPROPYL AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2015-06-18 | — | — | US | disclosed |
| US-9012452-B2 | Processes for making cyclopropyl amide derivatives and intermediates associated therewith | ASTRAZENECA AB (SE) | 2015-04-21 | — | — | US | disclosed |
| US-9012452-B2 | Processes for making cyclopropyl amide derivatives and intermediates associated therewith | ASTRAZENECA AB (SE) | 2015-04-21 | — | — | US | disclosed |
| EP-2536685-B1 | PROCESSES FOR MAKING CYCLOPROPYL AMIDE DERIVATIVES AND INTERMEDIATES ASSOCIATED THEREWITH | ASTRAZENECA AB (SE) | 2015-04-08 | — | — | EP | disclosed |
| US-8993577-B2 | Cyclopropyl amide derivatives | ASTRAZENECA AB (SE) | 2015-03-31 | — | — | US | disclosed |
| US-8993577-B2 | Cyclopropyl amide derivatives | ASTRAZENECA AB (SE) | 2015-03-31 | — | — | US | disclosed |
| US-20130172560-A1 | PROCESSES FOR MAKING CYCLOPROPYL AMIDE DERIVATIVES AND INTERMEDIATES ASSOCIATED THEREWITH | ASTRAZENECA AB (SE) | 2013-07-04 | — | — | US | disclosed |
| US-20130172560-A1 | PROCESSES FOR MAKING CYCLOPROPYL AMIDE DERIVATIVES AND INTERMEDIATES ASSOCIATED THEREWITH | ASTRAZENECA AB (SE) | 2013-07-04 | — | — | US | disclosed |
| EP-2398780-B1 | CYCLOPROPYL AMIDE DERIVATIVES TARGETING THE HISTAMINE H3 RECEPTOR | ASTRAZENECA AB (SE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2398780-B1 | CYCLOPROPYL AMIDE DERIVATIVES TARGETING THE HISTAMINE H3 RECEPTOR | ASTRAZENECA AB (SE) | 2013-04-17 | — | — | EP | disclosed |
| WO-2011102794-A1 | PROCESSES FOR MAKING CYCLOPROPYL AMIDE DERIVATIVES AND INTERMEDIATES ASSOCIATED THEREWITH | ASTRAZENECA AB (SE) | 2011-08-25 | — | — | WO | disclosed |
| WO-2011102793-A1 | SOLID FORMS COMPRISING A CYCLOPROPYL AMIDE DERIVATIVE | ASTRAZENECA AB (SE) | 2011-08-25 | — | — | WO | disclosed |
| US-20110201622-A1 | Solid Forms Comprising A Cyclopropyl Amide Derivative | ASTRAZENECA PHARMACEUTICALS LP | 2011-08-18 | — | — | US | disclosed |
| US-20100216812-A1 | Cyclopropyl Amide Derivatives | ASTRAZENECA AB (SE) | 2010-08-26 | — | — | US | disclosed |
| US-20100216812-A1 | Cyclopropyl Amide Derivatives | ASTRAZENECA AB (SE) | 2010-08-26 | — | — | US | disclosed |
| WO-2010096011-A1 | CYCLOPROPYL AMIDE DERIVATIVES TARGETING THE HISTAMINE H3 RECEPTOR | ASTRAZENECA AB (SE) | 2010-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201622-A1 | Solid Forms Comprising A Cyclopropyl Amide Derivative | SFPQ, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, SBDS | HTR6 3827/4885BIRC2 3074/4885CYP2C9 115/4885 |
| US-20130172560-A1 | PROCESSES FOR MAKING CYCLOPROPYL AMIDE DERIVATIVES AND INTERMEDIATES ASSOCIATED THEREWITH | HRH4, HRH2, HRH3 | HTR6 209/4885BIRC2 4817/4885CYP2C9 198/4885 |
| US-20100216812-A1 | Cyclopropyl Amide Derivatives | HRH4, HRH2, HRH3 | HTR6 88/4885BIRC2 3544/4885CYP2C9 3178/4885 |
| US-20150164888-A1 | CYCLOPROPYL AMIDE DERIVATIVES | HRH4, HRH2, HRH3 | HTR6 88/4885BIRC2 3544/4885CYP2C9 3178/4885 |
| US-20150164889-A1 | CYCLOPROPYL AMIDE DERIVATIVES | HRH4, HRH2, HRH3 | HTR6 88/4885BIRC2 3544/4885CYP2C9 3178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.