Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 4/20 | 0.61 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | PGK1 | P00558 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21217198 | 0.83 | NCF1 (0.53) | NCF1SLC2A1GRM5KCNH2MCHR1 | |
| SCHEMBL27060737 | 0.83 | NCF1 (0.65) | NCF1SLC2A1GRM5KCNH2MCHR1 | |
| SCHEMBL2253396 | 0.82 | CYP1A2 (0.55) | SLC2A1LMNASMN1; SMN2HPGDCYP1A2 | |
| SCHEMBL12356709 | 0.79 | NCF1 (0.51) | NCF1SLC2A1GRM5KCNH2BCHE | |
| SCHEMBL12356730 | 0.78 | NCF1 (0.50) | NCF1KCNH2BCHEACHEAPP | |
| SCHEMBL12356706 | 0.78 | NCF1 (0.56) | NCF1KCNH2BCHEACHEPOLB | |
| SCHEMBL12356704 | 0.78 | NCF1 (0.50) | NCF1GRM5KCNH2BCHEACHE | |
| SCHEMBL13040668 | 0.77 | NCF1 (0.63) | NCF1POLBLMNASMN1; SMN2HPGD | |
| SCHEMBL31109926 | 0.77 | NCF1 (0.50) | NCF1SLC2A1GRM5KCNH2RAF1 | |
| SCHEMBL21195763 | 0.77 | NCF1 (0.50) | NCF1SLC2A1GRM5KCNH2RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989628-B2 | 2-aminoquinolines | HOFFMANN-LA ROCHE INC. (US) | 2011-08-02 | — | — | US | disclosed |
| US-20090227628-A1 | 2-AMINOQUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227628-A1 | 2-AMINOQUINOLINES | HTR5A, HTR1A, HTR1E | NCF1 2971/4885SLC2A1 2139/4885GRM5 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.