Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 6/20 | 0.54 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PYGL | P06737 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12365698 | 0.87 | SRD5A2 (0.51) | SRD5A2SRD5A1TSHRTTRKDM4E | |
| SCHEMBL12365317 | 0.87 | SRD5A2 (0.51) | SRD5A2SRD5A1TSHRTTRALDH1A1 | |
| SCHEMBL12365330 | 0.87 | MAPK14 (0.43) | SRD5A2SRD5A1TSHRTTRALDH1A1 | |
| SCHEMBL12365696 | 0.87 | SRD5A2 (0.42) | SRD5A2SRD5A1TSHRSMN1; SMN2TTR | |
| SCHEMBL12365839 | 0.86 | SRD5A2 (0.49) | SRD5A2SRD5A1TSHRTTRALDH1A1 | |
| SCHEMBL12365007 | 0.85 | SRD5A2 (0.49) | SRD5A2SRD5A1TSHRSMN1; SMN2TTR | |
| SCHEMBL12365327 | 0.85 | SLC6A3 (0.46) | SRD5A2SRD5A1SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL12366052 | 0.85 | SRD5A2 (0.49) | SRD5A2SRD5A1TSHRTTRALDH1A1 | |
| SCHEMBL12365786 | 0.85 | SRD5A2 (0.48) | SRD5A2SRD5A1TSHRSMN1; SMN2TTR | |
| SCHEMBL12389206 | 0.84 | SRD5A2 (0.48) | SRD5A2SRD5A1TTRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110207729-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2011-08-25 | — | — | US | disclosed |
| US-20110207729-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2011-08-25 | — | — | US | disclosed |
| EP-2177505-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2010-04-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207729-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | SRD5A2 412/4885SRD5A1 247/4885TSHR 821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.