Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 6/20 | 0.49 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | F11 | P03951 | 2/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | CDH1 | P12830 | 1/20 | 0.33 |
| ▸ | APC | P25054 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12365662 | 0.86 | SLC6A3 (0.36) | SRD5A2SRD5A1ALDH1A1MAPT | |
| SCHEMBL12365096 | 0.86 | MAPK14 (0.42) | SRD5A2SRD5A1ALDH1A1TTRTDP2 | |
| SCHEMBL12365322 | 0.86 | SRD5A2 (0.38) | SRD5A2SRD5A1ALDH1A1TSHRMAPT | |
| SCHEMBL12365029 | 0.85 | SRD5A2 (0.46) | SRD5A2SRD5A1ALDH1A1TTRHSP90AA1 | |
| SCHEMBL12365335 | 0.85 | SRD5A2 (0.54) | SRD5A2SRD5A1ALDH1A1TTRALOX15 | |
| SCHEMBL12366937 | 0.85 | HTR2B (0.45) | SRD5A2SRD5A1 | |
| SCHEMBL12365317 | 0.83 | SRD5A2 (0.51) | SRD5A2SRD5A1ALDH1A1TTRALOX15 | |
| SCHEMBL12365698 | 0.83 | SRD5A2 (0.51) | SRD5A2SRD5A1ALDH1A1TTRALOX15 | |
| SCHEMBL12365323 | 0.83 | KDM4E (0.43) | SRD5A2SRD5A1ALDH1A1MAPTAKR1C3 | |
| SCHEMBL12365839 | 0.81 | SRD5A2 (0.49) | SRD5A2SRD5A1ALDH1A1TTRALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110207729-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2011-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207729-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | SRD5A2 412/4885SRD5A1 247/4885ALDH1A1 934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.