Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.38 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | GRK6 | P43250 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12365441 | 0.87 | TTR (0.45) | ALDH1A1SRD5A2SRD5A1MAPK14TDP2 | |
| SCHEMBL12365239 | 0.87 | MAPK14 (0.43) | KDM4CALDH1A1SRD5A2SRD5A1MAPK14 | |
| SCHEMBL12365342 | 0.86 | SRD5A2 (0.43) | ALDH1A1SRD5A2SRD5A1MAPK14TDP2 | |
| SCHEMBL12366152 | 0.85 | MAPK14 (0.41) | KDM4CMAPK14CYP3A4CYP11B2ROCK2 | |
| SCHEMBL12365863 | 0.85 | KDM4C (0.47) | KDM4CALDH1A1SRD5A2SRD5A1MAPK14 | |
| SCHEMBL12366114 | 0.85 | SRD5A2 (0.40) | KDM4CALDH1A1SRD5A2SRD5A1HCAR2 | |
| SCHEMBL12365445 | 0.84 | ALDH1A1 (0.40) | KDM4CALDH1A1SRD5A2SRD5A1MAPK14 | |
| SCHEMBL2262833 | 0.83 | HTR5A (0.51) | — | |
| SCHEMBL12365539 | 0.82 | HCAR2 (0.43) | KDM4CALDH1A1SRD5A2SRD5A1MAPK14 | |
| SCHEMBL12365395 | 0.81 | LMNA (0.46) | ALDH1A1SRD5A2SRD5A1MAPK14LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110207729-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2011-08-25 | — | — | US | disclosed |
| US-20110207729-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2011-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207729-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | KDM4C 1796/4885ALDH1A1 934/4885SRD5A2 412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.