Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13073769 | 0.80 | KMT2A (0.59) | KMT2AMEN1MAPTGAACHRNB2 | |
| SCHEMBL1284855 | 0.80 | KMT2A (0.59) | KMT2AMEN1MAPTGAACHRNB2 | |
| SCHEMBL22323341 | 0.79 | MEN1 (0.66) | KMT2AMEN1MAPTGAACHRNB2 | |
| SCHEMBL12366090 | 0.78 | ALDH1A1 (0.57) | KMT2AMEN1GAASMN1; SMN2LMNA | |
| SCHEMBL12366181 | 0.78 | KMT2A (0.54) | KMT2AMEN1MAPTLMNACA2 | |
| SCHEMBL12366141 | 0.78 | NPC1 (0.62) | KMT2AMEN1SMN1; SMN2LMNAHPGD | |
| SCHEMBL12366133 | 0.78 | HPGD (0.54) | KMT2AMEN1MAPTSMN1; SMN2LMNA | |
| SCHEMBL5697805 | 0.78 | MEN1 (0.57) | KMT2AMEN1MAPTGAACHRNB2 | |
| SCHEMBL17537295 | 0.78 | KMT2A (0.57) | KMT2AMEN1MAPTGAACHRNB2 | |
| SCHEMBL1566774 | 0.77 | MEN1 (0.64) | KMT2AMEN1MAPTGAACHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |