Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | PPIA | P62937 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12366179 | 0.88 | P2RX7 (0.46) | HPGDSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL12366170 | 0.81 | CNR1 (0.46) | SMN1; SMN2LMNAALDH1A1RAB9AMAPT | |
| SCHEMBL12366137 | 0.81 | P2RX7 (0.50) | MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL12366090 | 0.81 | ALDH1A1 (0.57) | HPGDSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL12366181 | 0.81 | KMT2A (0.54) | LMNAMEN1KMT2ARIPK1ALDH1A1 | |
| SCHEMBL12366141 | 0.81 | NPC1 (0.62) | HPGDSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL12366112 | 0.80 | EPHX2 (0.51) | MEN1KMT2A | |
| SCHEMBL12366166 | 0.79 | P2RX7 (0.49) | — | |
| SCHEMBL12366210 | 0.79 | ERCC1 (0.40) | HPGDSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL12366196 | 0.78 | KMT2A (0.58) | HPGDSMN1; SMN2LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |