Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RGS4 | P49798 | 1/20 | 0.43 |
| ▸ | RGS8 | P57771 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12366278 | 0.94 | MAPT (0.45) | RGS4RGS8CTSKTP53MAPT | |
| SCHEMBL12366212 | 0.91 | CNR1 (0.44) | RGS4RGS8LMNARXFP1CFTR | |
| SCHEMBL12366275 | 0.89 | CFTR (0.42) | RGS4RGS8CFTRCNR1 | |
| SCHEMBL12366571 | 0.88 | CNR1 (0.37) | RGS4RGS8CNR1 | |
| SCHEMBL12366582 | 0.88 | CNR1 (0.37) | RGS4RGS8CFTRCNR1 | |
| SCHEMBL12366233 | 0.88 | CNR1 (0.42) | RGS4RGS8TP53MAPTCNR1 | |
| SCHEMBL12366220 | 0.88 | CNR1 (0.39) | RGS4RGS8TP53RXFP1CFTR | |
| SCHEMBL12366945 | 0.88 | CNR1 (0.37) | RGS4RGS8CTSKRXFP1CFTR | |
| SCHEMBL12366286 | 0.88 | MAPT (0.45) | TP53MAPTLMNARXFP1GRIN1 | |
| SCHEMBL12366238 | 0.86 | DCTPP1 (0.42) | RXFP1S1PR5CFTRCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |