Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | RGS4 | P49798 | 1/20 | 0.41 |
| ▸ | RGS8 | P57771 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 2/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12366226 | 0.94 | RGS4 (0.43) | MAPTTP53LMNARXFP1RGS4 | |
| SCHEMBL12366212 | 0.91 | CNR1 (0.44) | LMNARXFP1RGS4RGS8KDM4E | |
| SCHEMBL12366286 | 0.90 | MAPT (0.45) | MAPTTP53LMNARXFP1KDM4E | |
| SCHEMBL12366396 | 0.89 | RXRA (0.41) | MAPTTP53LMNAKDM4EALDH1A1 | |
| SCHEMBL12366275 | 0.89 | CFTR (0.42) | RGS4RGS8KDM4EFABP4PPARG | |
| SCHEMBL12366441 | 0.88 | LMNA (0.43) | MAPTLMNARXFP1ALDH1A1FEN1 | |
| SCHEMBL12366241 | 0.88 | CNR1 (0.42) | MAPTTP53LMNAKDM4EALDH1A1 | |
| SCHEMBL12366238 | 0.86 | DCTPP1 (0.42) | RXFP1KDM4EALDH1A1PPARG | |
| SCHEMBL12366220 | 0.86 | CNR1 (0.39) | TP53RXFP1RGS4RGS8KDM4E | |
| SCHEMBL12366421 | 0.85 | RXRA (0.39) | RXFP1KDM4EALDH1A1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |