Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | ICMT | O60725 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12366256 | 0.94 | POLB (0.38) | MAPTTP53POLBALDH1A1KDM4E | |
| SCHEMBL12366288 | 0.91 | MDM2 (0.41) | — | |
| SCHEMBL12366233 | 0.91 | CNR1 (0.42) | MAPTTP53ALDH1A1KDM4EGAA | |
| SCHEMBL12366418 | 0.90 | MAPT (0.42) | MAPTTP53POLBALDH1A1KDM4E | |
| SCHEMBL12366278 | 0.90 | MAPT (0.45) | MAPTTP53POLBALDH1A1KDM4E | |
| SCHEMBL12366472 | 0.89 | LMNA (0.45) | MAPTTP53POLBALDH1A1LMNA | |
| SCHEMBL12366740 | 0.89 | PTGS2 (0.35) | MAPTTP53ICMTPOLBLMNA | |
| SCHEMBL12366241 | 0.89 | CNR1 (0.42) | MAPTTP53POLBALDH1A1KDM4E | |
| SCHEMBL12366250 | 0.89 | MAPT (0.40) | MAPTTP53 | |
| SCHEMBL12366465 | 0.88 | MDM2 (0.36) | MAPTTP53POLBGRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |