Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | TP53 | P04637 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RGS4 | P49798 | 1/20 | 0.36 |
| ▸ | RGS8 | P57771 | 1/20 | 0.36 |
| ▸ | CLPP | Q16740 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12366241 | 0.95 | CNR1 (0.42) | POLBMEN1KMT2AMAPTTP53 | |
| SCHEMBL12366233 | 0.95 | CNR1 (0.42) | MEN1KMT2AMAPTTP53ALDH1A1 | |
| SCHEMBL12366286 | 0.94 | MAPT (0.45) | POLBMAPTTP53LMNAALDH1A1 | |
| SCHEMBL12366418 | 0.94 | MAPT (0.42) | POLBMAPTTP53LMNAALDH1A1 | |
| SCHEMBL12366472 | 0.93 | LMNA (0.45) | POLBMEN1KMT2AMAPTTP53 | |
| SCHEMBL12366740 | 0.93 | PTGS2 (0.35) | POLBMEN1KMT2AMAPTTP53 | |
| SCHEMBL12366250 | 0.93 | MAPT (0.40) | MAPTTP53MDM2CNR1PTGS1 | |
| SCHEMBL12366465 | 0.92 | MDM2 (0.36) | POLBMAPTTP53CLPPMDM2 | |
| SCHEMBL12366743 | 0.91 | MDM2 (0.34) | MAPTTP53LMNAALDH1A1HTT | |
| SCHEMBL12366450 | 0.91 | MDM2 (0.40) | POLBMAPTTP53LMNACLPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |