Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Methionine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 4/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Racemethionine SCHEMBL18351662 | 1.00 | KIF11 (0.45) | KIF11CYP2D6MAPK1CA2CA1 | |
| Racemethionine SCHEMBL1236856 | 1.00 | KIF11 (0.45) | KIF11CYP2D6MAPK1CA2CA1 | |
| Methionine SCHEMBL15688811 | 1.00 | KIF11 (0.45) | KIF11CYP2D6MAPK1CA2CA1 | |
| Racemethionine SCHEMBL29260976 | 0.99 | KIF11 (0.46) | KIF11CYP2D6MAPK1CA2CA1 | |
| Methionine SCHEMBL30298013 | 0.99 | KIF11 (0.46) | KIF11CYP2D6MAPK1CA2CA1 | |
| Racemethionine SCHEMBL1236851 | 0.92 | KIF11 (0.41) | KIF11CYP2D6MAPK1CA2CA1 | |
| P-Toluenesulfonamide SCHEMBL6645676 | 0.88 | CA2 (0.56) | KIF11CA2CA1KDM4EPOLB | |
| P-Toluenesulfonamide SCHEMBL6645679 | 0.88 | CA2 (0.56) | KIF11CA2CA1KDM4EPOLB | |
| P-Toluenesulfonamide SCHEMBL6642628 | 0.86 | CA2 (0.55) | KIF11CA2CA1MMP2 | |
| P-Toluenesulfonamide SCHEMBL6642631 | 0.86 | CA2 (0.55) | KIF11CA2CA1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010079287-A1 | DIVISIBLE TABLET CONTAINING PARTICLES COATED WITH S-ADENOSYL-METHIONINE | VETOQUINOL S.A. (FR) | 2010-07-15 | — | — | WO | claimed |
| EP-3131557-A2 | NOVEL ADEMETIONINE FORMULATIONS | Methylation Sciences International SRL (BB) | 2017-02-22 | — | — | EP | disclosed |
| WO-2015159155-A2 | NOVEL ADEMETIONINE FORMULATIONS | METHYLATION SCIENCES INTERNATIONAL SRL (BB) | 2015-10-22 | — | — | WO | disclosed |
| EP-2464358-A2 | IMPROVED PHARMACOKINETICS OF S-ADENOSYLMETHIONINE FORMULATIONS | Methylation Sciences International SRL (BB) | 2012-06-20 | — | — | EP | disclosed |
| WO-2011012990-A2 | IMPROVED PHARMACOKINETICS OF S-ADENOSYLMETHIONINE FORMULATIONS | METHYLATION SCIENCES INTERNATIONAL SRL (BB) | 2011-02-03 | — | — | WO | disclosed |