SCHEMBL12371112

SCHEMBL12371112

CCCCn1nc(C(F)(F)F)cc1O[C@@H]1[C@@H]2CC[C@H]1CNC2

nearest known ligand 0.33

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.33
HTR2C P28335 5/20 0.32
HTR2A P28223 4/20 0.32
HTR2B P41595 4/20 0.32
CHRNA1 P02708 1/20 0.32
CHRNG P07510 1/20 0.32
CHRNB1 P11230 1/20 0.32
CHRNB2 P17787 1/20 0.32
CHRNB4 P30926 1/20 0.32
CHRNA3 P32297 1/20 0.32
CHRNA7 P36544 1/20 0.32
CHRNA4 P43681 1/20 0.32
CHRND Q07001 1/20 0.32
TGFBR1 P36897 2/20 0.31
CTSS P25774 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL760376 1.00 LMNA (0.33) LMNAHTR2CHTR2AHTR2BCHRNA1
SCHEMBL12371110 0.77 HCRTR1 (0.42) LMNA
SCHEMBL12371131 0.77 HCRTR1 (0.42) LMNA
SCHEMBL758584 0.74 HTR2C (0.31) HTR2C
SCHEMBL759181 0.72 CNR2 (0.31) TGFBR1
SCHEMBL27719767 0.70 MPO (0.40) LMNAHTR2C
SCHEMBL756547 0.68 HRH3 (0.44) LMNA
SCHEMBL20381740 0.67 CNR1 (0.47) LMNA
SCHEMBL27507519 0.66 LMNA (0.43) LMNA
SCHEMBL27667658 0.66 LMNA (0.40) LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7994094-B2 N-pyridylpiperidine compound, method for producing the same, and pest control agent OTSUKA AGRITECHNO CO., LTD. (JP) 2011-08-09 US disclosed
US-20100137582-A1 N-PYRIDYLPIPERIDINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND PEST CONTROL AGENT OTSUKA CHEMICAL CO., LTD. (JP) 2010-06-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100137582-A1 N-PYRIDYLPIPERIDINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND PEST CONTROL AGENT HRH4, NOX4, PRDX4 LMNA 4100/4885HTR2C 1610/4885HTR2A 1835/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.