Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.83 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.83 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.83 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.83 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.83 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.83 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.83 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.83 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.83 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.83 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.83 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7129534 | 0.93 | HDAC3 (0.73) | HDAC8HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL7369775 | 0.87 | HDAC3 (0.65) | HDAC8HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL8610330 | 0.87 | HDAC8 (0.65) | HDAC8HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL27742472 | 0.87 | HDAC3 (0.70) | HDAC8HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL23080120 | 0.84 | HDAC3 (0.66) | HDAC8HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL14675977 | 0.84 | HDAC3 (0.66) | HDAC8HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL2097555 | 0.83 | HDAC3 (0.64) | HDAC8HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL14075748 | 0.82 | HDAC3 (0.64) | HDAC8HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL27396745 | 0.82 | HDAC3 (0.64) | HDAC8HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL27942322 | 0.82 | HDAC3 (0.64) | HDAC8HDAC3HDAC1HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180098950-A1 | INHIBITORS OF ABETA AND SYNUCLEIN AGGREGATION | THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (US) | 2018-04-12 | — | — | US | disclosed |
| US-8865641-B2 | Methods of treatment of fatty liver disease by pharmacological activation of cholinergic pathways | THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (US) | 2014-10-21 | — | — | US | disclosed |
| US-20120322719-A1 | METHODS OF TREATMENT OF FATTY LIVER DISEASE BY PHARMACOLOGICAL ACTIVATION OF CHOLINERGIC PATHWAYS | THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (US) | 2012-12-20 | — | — | US | disclosed |
| US-20110201686-A1 | Inhibitors of ASS and Synuclein Aggregation | AL-ABED YOUSEF | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201686-A1 | Inhibitors of ASS and Synuclein Aggregation | SNCA, ASS1, PRNP | HDAC8 1562/4885HDAC3 1355/4885HDAC1 738/4885 |
| US-20180098950-A1 | INHIBITORS OF ABETA AND SYNUCLEIN AGGREGATION | SNCA, PRNP, PYGB | HDAC8 3746/4885HDAC3 3875/4885HDAC1 2806/4885 |
| US-20120322719-A1 | METHODS OF TREATMENT OF FATTY LIVER DISEASE BY PHARMACOLOGICAL ACTIVATION OF CHOLINERGIC PATHWAYS | CHAT, CHKB, CHRM2 | HDAC8 553/4885HDAC3 544/4885HDAC1 1287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.