Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.51 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | F12 | P00748 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1445862 | 0.83 | DHFR (0.45) | TRPA1RAB9AARENPP1IDO1 | |
| SCHEMBL31674009 | 0.79 | ALDH1A1 (0.40) | TRPA1MPOPDE10ARAB9ABACE1 | |
| SCHEMBL1446097 | 0.78 | PARP1 (0.46) | TRPA1PDE10ARAB9ACYP2A6F12 | |
| SCHEMBL1445724 | 0.76 | ADRA2A (0.53) | RAB9ACYP2A6F12PLAUNCF1 | |
| SCHEMBL28558960 | 0.72 | CYP2A6 (0.50) | RAB9AARCYP2A6F12PLAU | |
| SCHEMBL7381639 | 0.72 | PLAU (0.50) | RAB9AARCYP2A6F12PLAU | |
| SCHEMBL1445282 | 0.72 | C1R (0.42) | RAB9ACYP2A6F12PLAUNCF1 | |
| SCHEMBL8559774 | 0.72 | RAB9A (0.56) | PDE10ARAB9AARCYP2A6CYP1A2 | |
| SCHEMBL17664456 | 0.71 | CYP1A2 (0.43) | TRPA1PDE10ARAB9AADORA2AADORA1 | |
| SCHEMBL12402242 | 0.71 | CYP1A2 (0.46) | BACE1CYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999090-B2 | reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered; antifungal agents; inhibiting expression of cell wall glycoproteins and preventing pathogens from showing pathogenicity; DNA | EISAI CO., LTD (JP) | 2011-08-16 | — | — | US | disclosed |
| US-7999090-B2 | reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered; antifungal agents; inhibiting expression of cell wall glycoproteins and preventing pathogens from showing pathogenicity; DNA | EISAI CO., LTD (JP) | 2011-08-16 | — | — | US | disclosed |
| US-20080261272-A1 | FUNGAL CELL WALL SYNTHESIS GENE | EISAI R&D MANAGEMENT CO., LTD (JP) | 2008-10-23 | — | — | US | disclosed |
| US-20080261272-A1 | FUNGAL CELL WALL SYNTHESIS GENE | EISAI R&D MANAGEMENT CO., LTD (JP) | 2008-10-23 | — | — | US | disclosed |