Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 9/20 | 1.00 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2279814 | 0.86 | PTGS1 (0.75) | PTGS1CA1CA2CA4CA7 | |
| SCHEMBL12374641 | 0.83 | PTGS1 (1.00) | PTGS1POLBKDM4EALDH1A1LMNA | |
| SCHEMBL2280445 | 0.81 | PTGS1 (1.00) | PTGS1POLBALDH1A1SMN1; SMN2GAA | |
| SCHEMBL12406050 | 0.80 | PTGS1 (0.67) | PTGS1KDM4EMAPT | |
| SCHEMBL22570862 | 0.80 | PTGS1 (0.73) | PTGS1POLBKDM4EALDH1A1LMNA | |
| SCHEMBL5777104 | 0.75 | PTGS1 (0.65) | PTGS1POLBKDM4EALDH1A1LMNA | |
| SCHEMBL16502243 | 0.74 | PTGS1 (0.73) | PTGS1KDM4EALDH1A1LMNATP53 | |
| SCHEMBL6696047 | 0.74 | PTGS1 (0.64) | PTGS1POLBKDM4EALDH1A1LMNA | |
| SCHEMBL12405718 | 0.73 | PTGS1 (0.69) | PTGS1 | |
| SCHEMBL13438 | 0.72 | PTGS1 (0.69) | PTGS1KDM4EALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989450-B2 | Functionalized diarylisoxazoles inhibitors of ciclooxygenase | UNIVERSITA' DEGLI STUDI DI BARI (IT) | 2011-08-02 | — | — | US | disclosed |
| US-20090181970-A1 | Functionalized diarylisoxazoles inhibitors of ciclooxygenase | UNIVERSITA' DEGLI STUDI DI BARI (IT) | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181970-A1 | Functionalized diarylisoxazoles inhibitors of ciclooxygenase | PTGIS, ALOX5, ALOX15 | PTGS1 4/4885POLB 2568/4885KDM4E 3409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.