SCHEMBL12376968

SCHEMBL12376968

COc1ccc(-c2ccc(OC(=O)c3ccc(Oc4ccc(C(C)=O)cc4)cc3)c(C)c2)cc1C

nearest known ligand 0.50

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.50
MAPT P10636 8/20 0.49
HPGD P15428 1/20 0.49
RAB9A P51151 1/20 0.49
TP53 P04637 1/20 0.47
GAA P10253 1/20 0.46
TDP1 Q9NUW8 1/20 0.43
HAVCR2 Q8TDQ0 1/20 0.42
THRB P10828 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2C9 P11712 1/20 0.42
KDM4E B2RXH2 1/20 0.41
ALDH1A1 P00352 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15249585 0.92 KMT2A (0.52) KMT2AMAPTHPGDRAB9AGAA
SCHEMBL12376964 0.88 KMT2A (0.48) KMT2AMAPTHPGDRAB9AGAA
SCHEMBL12376959 0.86 KMT2A (0.47) KMT2AMAPTHPGDRAB9AGAA
SCHEMBL12404390 0.86 KMT2A (0.47) KMT2AMAPTHPGDRAB9AGAA
SCHEMBL12376962 0.85 KMT2A (0.46) KMT2AMAPTHPGDRAB9ATP53
SCHEMBL12404355 0.85 KMT2A (0.49) KMT2AMAPTHPGDRAB9AGAA
SCHEMBL19763410 0.85 KMT2A (0.49) KMT2AMAPTHPGDRAB9AGAA
SCHEMBL19863503 0.84 KMT2A (0.41) KMT2AMAPTHPGDRAB9ATP53
SCHEMBL16573871 0.84 MAPT (0.60) KMT2AMAPTHPGDRAB9ATP53
SCHEMBL12404366 0.83 KMT2A (0.47) KMT2AMAPTHPGDRAB9ATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9746816-B2 Image forming apparatus and electrophotographic cartridge MITSUBISHI CHEMICAL CORPORATION (JP) 2017-08-29 US disclosed
US-20170205719-A1 IMAGE FORMING APPARATUS AND ELECTROPHOTOGRAPHIC CARTRIDGE MITSUBISHI CHEMICAL CORPORATION (JP) 2017-07-20 US disclosed
US-20110206411-A1 IMAGE FORMING APPARATUS AND ELECTROPHOTOGRAPHIC CARTRIDGE MITSUBISHI CHEMICAL CORPORATION (JP) 2011-08-25 US disclosed