SCHEMBL12404355

SCHEMBL12404355

COc1ccc(Cc2ccc(OC(=O)c3ccc(Oc4ccc(C(=O)Oc5ccc(Oc6ccc(OC(=O)c7ccc(Oc8ccc(C(C)=O)cc8)cc7)cc6)cc5)cc4)cc3)c(C)c2)cc1C

nearest known ligand 0.49

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 8/20 0.49
L3MBTL1 Q9Y468 2/20 0.44
MAPT P10636 6/20 0.44
HPGD P15428 1/20 0.44
RAB9A P51151 1/20 0.44
TDP1 Q9NUW8 1/20 0.43
GAA P10253 2/20 0.43
GLA P06280 1/20 0.41
TSHR P16473 1/20 0.41
SRD5A2 P31213 1/20 0.40
KDM4E B2RXH2 1/20 0.40
POLB P06746 1/20 0.40
MAPK1 P28482 1/20 0.40
ALDH1A1 P00352 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19763410 1.00 KMT2A (0.49) KMT2AL3MBTL1MAPTHPGDRAB9A
SCHEMBL12376964 0.98 KMT2A (0.48) KMT2AL3MBTL1MAPTHPGDRAB9A
SCHEMBL12903847 0.95 L3MBTL1 (0.50) KMT2AL3MBTL1MAPTHPGDRAB9A
SCHEMBL14444754 0.95 KMT2A (0.51) KMT2AL3MBTL1MAPTTDP1GAA
SCHEMBL12376952 0.92 KMT2A (0.49) KMT2AL3MBTL1MAPTTDP1GAA
SCHEMBL15249585 0.88 KMT2A (0.52) KMT2AL3MBTL1MAPTHPGDRAB9A
SCHEMBL12404378 0.88 NPC1 (0.46) KMT2AL3MBTL1MAPTHPGDRAB9A
SCHEMBL12376968 0.85 KMT2A (0.50) KMT2AMAPTHPGDRAB9ATDP1
SCHEMBL13324844 0.85 KMT2A (0.46) KMT2AL3MBTL1MAPTTDP1GAA
SCHEMBL13324838 0.84 KMT2A (0.46) KMT2AL3MBTL1MAPTTDP1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7985522-B2 Electrophotographic photoreceptor MITSUBISHI CHEMICAL CORPORATION (JP) 2011-07-26 US disclosed
US-20110013934-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR MITSUBISHI CHEMICAL CORPORATION (JP) 2011-01-20 US disclosed
US-20090047589-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR MITSUBISHI CHEMICAL CORPORATION (JP) 2009-02-19 US disclosed