SCHEMBL12376974

SCHEMBL12376974

CCOc1cccc(/C=C/c2ccc(N(c3ccc(C)cc3)c3ccc(C)cc3)cc2)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.52
ALDH1A1 P00352 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
RELA Q04206 3/20 0.51
LCK P06239 1/20 0.47
ESR1 P03372 2/20 0.47
AHR P35869 1/20 0.47
NFE2L2 Q16236 3/20 0.46
MAOB P27338 4/20 0.46
MAOA P21397 3/20 0.46
MEN1 O00255 1/20 0.43
NPC1 O15118 1/20 0.43
MAPT P10636 1/20 0.43
THRB P10828 1/20 0.43
MAPK1 P28482 1/20 0.43
RAB9A P51151 1/20 0.43
KMT2A Q03164 1/20 0.43
ATM Q13315 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
CYP19A1 P11511 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4237316 0.85 RELA (0.66) RELANFE2L2CYP19A1CHRNA7
SCHEMBL4237317 0.85 RELA (0.66) RELANFE2L2CYP19A1CHRNA7
SCHEMBL7905688 0.85 RELA (0.66) RELANFE2L2CYP19A1CHRNA7
SCHEMBL7905686 0.85 RELA (0.66) RELANFE2L2CYP19A1CHRNA7
SCHEMBL16489730 0.85 RELA (0.61) KDM4EALDH1A1SMN1; SMN2RELAESR1
SCHEMBL12376972 0.85 RELA (0.61) KDM4EALDH1A1SMN1; SMN2RELAESR1
SCHEMBL14665948 0.85 RELA (0.61) KDM4EALDH1A1SMN1; SMN2RELAESR1
SCHEMBL15499181 0.84 KDM4E (0.46) KDM4EALDH1A1SMN1; SMN2RELALCK
SCHEMBL4402172 0.83 NFE2L2 (0.59) RELANFE2L2CYP19A1
SCHEMBL7905694 0.83 RELA (0.71) RELAESR1AHRNFE2L2CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9746816-B2 Image forming apparatus and electrophotographic cartridge MITSUBISHI CHEMICAL CORPORATION (JP) 2017-08-29 US disclosed
US-9746816-B2 Image forming apparatus and electrophotographic cartridge MITSUBISHI CHEMICAL CORPORATION (JP) 2017-08-29 US disclosed
US-20170205719-A1 IMAGE FORMING APPARATUS AND ELECTROPHOTOGRAPHIC CARTRIDGE MITSUBISHI CHEMICAL CORPORATION (JP) 2017-07-20 US disclosed
US-20170205719-A1 IMAGE FORMING APPARATUS AND ELECTROPHOTOGRAPHIC CARTRIDGE MITSUBISHI CHEMICAL CORPORATION (JP) 2017-07-20 US disclosed
US-20110206411-A1 IMAGE FORMING APPARATUS AND ELECTROPHOTOGRAPHIC CARTRIDGE MITSUBISHI CHEMICAL CORPORATION (JP) 2011-08-25 US disclosed